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Tri-i CBM held our annual retreat 10/27-28. We welcomed the new first years, had wonderful talks and discussions, and enjoyed rejuvenating group bonding time⭐️! Application portals are now open for perspective applicants, and we invite you to join our CBM family!

How are promoter interactions coordinated during cell differentiation? In our first paper, we investigate the temporal relationship between genome folding, transcription and histone modifications during ESC differentiation. (1)

Analysis of single-cell CRISPR perturbations indicates that enhancers predominantly act multiplicative cell.com/cell-genomics/…

Excited to share our latest preprint, as part of ENCODE4, on a consensus variant-to-function (cV2F) score for functionally prioritizing variants for complex disease - led by Tabassum Fabiha and co-mentored with Alkes Price. biorxiv.org/content/10.110…

Excited to announce our preprint describing SUPERB-SEQ 🦸, a new method to measure Cas9 edits and their effects on gene expression in single cells. Developed by Mickey Lorenzini, myself, and Graham McVicker biorxiv.org/content/10.110…

Introducing ColocBoost - a new multi-phenotype xQTL and GWAS colocalization method, that can handle multiple causal variants and scale to 100 phenotypes, led by xuewei cao , and co-mentored with Gao T. Wang . medrxiv.org/content/10.110…

We are excited to share our latest preprint, as part of ADSP Functional Genomics Consortium FunGen-xQTL project, on a method called ColocBoost for multi-trait colocalization analysis. Mentored by Gao T. Wang Kushal K Dey

pgBoost, led by Elizabeth Dorans , is now out in Nature Genetics : highlights the utility of genetic effects on gene expression (eQTLs) to benchmark and unify multiome peak-gene links and genomic distance. nature.com/articles/s4158…