Molecular biology and convergent / competitive evolution of these pathways continues to fascinate... HSV-1 deamidates cGAS buff.ly/2CJSC8A

Effect on HSC iron important component of eltrombopag activity- expands on the theme, anything involving hematopoiesis or erythropoiesis, iron metabolism is central Thrombopoietin receptor–independent stimulation of hematopoietic stem cells by eltrombopag buff.ly/2MnuEzy

Absolutely love Loch Lomond - enjoy guys!

Congrats to Dr Gahl and the NHGRI crew!

My first at bat with Dave Grayzel and the Atlas Venture team appears to be a home run. Exciting new therapy for people suffering with migraines coming soon. Lilly Receives Positive CHMP Opinion for Emgality™ for the Prophylaxis of Migraine in Adults prn.to/2xEJwVM

This is a terrific proposal from Noah Smith 🐇. It has many of its own merits. Additionally, it would create a powerful new constituency for the work Brookings Metro does with cities. bloomberg.com/view/articles/… via bopinion

FYI, on every New Hampshire plate

This is nuts - won’t be easy or cheap to move but have no idea how global tech keeps supply chain in China after this. Relevant lessons for other industries too. bloomberg.com/news/features/…

Interesting work on cellular identity in tumorigenesis. Also relevant for newer work on in-vivo transdifferentiation. More plasticity that we might assume! Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage buff.ly/2PcAohV

Sad day for Julio-Claudians and for the Empire. Give us Germanicus!

Have always had a soft spot for this biology, here very cool lineage tracing identifying cells that dedifferentiate/redifferentiate to rebuild - fibroblasts! Single-cell analysis uncovers convergence of cell identities during axolotl limb regeneration buff.ly/2PTZUIX

First findings from the most comprehensive genomic analysis of the human brain shed light on the roots of disorders such as schizophrenia and bipolar. go.nature.com/2BeUWQZ

What a great week for cannabinoid research- two structures of CB1 and CB2 published in Cell, one of which is from Stanford Medicine! @AbideTx justin cisar sciencedirect.com/science/articl… sciencedirect.com/science/articl…

New Forbes Health - "Novartis CEO Who Wanted To Bring Tech Into Pharma Now Explains Why It's So Hard" - forbes.com/sites/davidsha… Take-aways from recent, captivating Vas Narasimhan a16z interview Jorge Conde Vijay Pande Sonal Chokshi

Great review - human genetics super informative for target selection, but genetics and pharmacology not 1:1. Dose, functional impact, time of intervention, selectivity, tissue distribution, all key differences. See NaVs, romo CV effects, Aβ mAbs etc. biorxiv.org/content/10.110…

Petr Broz & Kaiwen Chen Benjamin Demarcay et al show how lytic cell death is prevented during caspase-8/9-mediated #apoptosis despite initial #gasdermin cleavage, with NLRP3 #inflammasome activation instead driven by channel-forming glycoprotein #pannexin emboj.embopress.org/content/early/…

We are excited to announce the launch of Start Codon, a new #lifescience accelerator based in #Cambridge, UK! Find out more about us & our investors, including @CambsInnovation, Babraham Institute, Genentech, Roche, Dr Jonathan Milner & Dr Ian Tomlinson here: bit.ly/2IQmcuz

The Promise Of Precision Neuroscience And Launch Of Arkuda Therapeutics With better molecular understanding of lysosomal biology, and insight into natural histories, its a gr8 time to target progranulin-deficient FTD with novel small molecule therapies lifescivc.com/2019/11/the-pr…

Disc Medicine today announced that John Quisel, JD, PhD, is joining @discmedicine as President and CEO in late February. Welcome! We are thrilled to have you! Read more at: discmedicine.com/news/john-quis…