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Leveraging #CRISPR activation screens, researchers identify the lipid metabolism protein ACBP as a key driver of bone metastasis, and show etomoxir or a ferroptosis inducer can prevent bone metastasis in mice. Li Ma, PhD MD Anderson Cancer Center scim.ag/4dAYFtY

Don't miss the new issue of #ScienceTranslationalMedicine! A clinical study uncovers a female-biased driver of mortality after severe trauma, systemic CAR T cells safely target colorectal cancer metastases in the liver in mice, and more. scim.ag/4jlxQLu

New research untangles how #GasderminD exacerbates the systemic storm after severe trauma and hemorrhagic shock—especially in female patients—but shows that disulfiram can improve survival in both sexes in mice. University of Pittsburgh scim.ag/43DDrXU

Why do #mengingococcus vaccines partially protect against #gonorrhea? Researchers identify antigens responsible for cross-protection and identify cross-reactive antibodies that can shield mice from gonococcus infection. Emanuele Andreano ToscanaLifeSciences scim.ag/3SNMwYX

Scientists identify cadherin-17 as a promising target for #CARTcells in colorectal cancer liver metastases, and find systemic delivery of anti-CDH17 cells suppresses tumors in mice while sparing healthy colon tissue. Ospedale San Raffaele scim.ag/4jtLQ6a

A new study in mice suggests that #fibrate medications may protect against cardiovascular disease by dampening inflammatory signaling in hepatocytes through PPAR-alpha, rather than by lowering lipids as previously thought. Infinite (U1286 Inserm | Univ. Lille | CHU Lille) scim.ag/4jn8Cwh

This issue, researchers tie the benefits of subcutaneous #immunotherapy for atopic dermatitis to a unique population of skin-resident regulatory T cells, which express the receptor ROR-gamma-t and originate in the periphery. TGIL Yonsei University College of Medicine scim.ag/43nbEMu

A team has designed a host defense peptide–mimicking prodrug that attacks drug-resistant Gram-negative bacteria at the infection site, decreasing the odds of treatment resistance and showing potency in five mouse models of bacterial infections. scim.ag/4jwPVGt

New research untangles how #GasderminD exacerbates the systemic storm after severe trauma and hemorrhagic shock—especially in female patients—but shows that disulfiram can improve survival in both sexes in mice. University of Pittsburgh scim.ag/43DDrXU

Excited to see the last publication from the Chandarlapaty’s lab in Science Translational Medicine, and always happy to contribute to uncover novel mechanisms of endocrine resistance in breast cancer. Memorial Sloan Kettering Cancer Center OncoAlert shorturl.at/MqYcC

The approved drug #methotrexate can potentiate antitumor immune activity and shows signs of boosting the efficacy of checkpoint blockade #immunotherapy in patients with solid tumors, according to a preliminary clinical trial. University of Chinese Academy of Sciences scim.ag/43yjwL9

Examining longitudinal data from 100 healthy people, researchers have identified four immunotypes that translate into different immune cell behavior, offering insight into immune system variation between individuals. Benaroya Research Institute Megan Smithmyer #Immunology scim.ag/3ZUbfPh

A new phase 1 clinical trial shows that an intra-articular #AAV #GeneTherapy is safe in humans with #osteoarthritis in the knee and increased the expression of an IL-1 receptor antagonist for as long as 1 year. Mayo Clinic PMR scim.ag/45Gpn2k

Don't miss the new issue of #ScienceTranslationalMedicine! An AI platform named DeepHeme accurately classifies bone marrow cells in patients, research suggests humans may be genetically programmed to produce antibodies against peanuts, and more. scim.ag/440Uaob

Humans may be genetically programmed to produce antibodies against peanut, suggests a new study showing nonallergic people harbor convergent, germline-encoded antibodies against the allergen Ara h 2. Sarita Patil, MD Orlee Marini-Rapoport MGH Rheumatology scim.ag/3HENnck

The approved drug #methotrexate can potentiate antitumor immune activity and shows signs of boosting the efficacy of checkpoint blockade #immunotherapy in patients with solid tumors, according to a preliminary clinical trial. University of Chinese Academy of Sciences scim.ag/43yjwL9

An #AI pipeline named DeepHeme can classify blood lineage cells in patients with bone marrow diseases, and performs well in a robust external dataset while matching the accuracy of a panel of medical experts. Goldgof Lab UCSF Bakar Computational Health Sciences Institute scim.ag/44fknR8

mRNA vaccines for #SARSCoV2 that use nonstabilized spike protein can still induce neutralizing antibodies against both variants of concern and related coronaviruses, show new experiments involving mice and macaques. The Haynes Lab Duke Human Vaccine Institute scim.ag/3Tzh29f

Synthetic bacteria reinvigorate immune cells to shrink colorectal cancer tumors in mice, a macrophage therapy can deliver powerful anticancer drugs to glioblastoma tumors, and more this week in #ScienceTranslationalMedicine. scim.ag/40b4GI9