Ribosome density is often used as a surrogate for translation efficiency. However, this article suggests differences in translation elongation rates across mRNAs: ⬛️ Translation elongation rates vary up to ∼ 20-fold among transcripts. 🧵

A new paper in Cell shows that it is possible (simple, really) to convert DNA-editing CRISPR proteins, such as Cas9, into RNA editors. All you have to do is delete a chunk of them. Deleting 55 amino acids from a DNA editor called IscB (the ancestor of Cas9) turned it into a

A new paper, in Nature Chemistry, proves that there are still tons of "basic" things to discover in biology. There is so much room at the bottom. TL;DR: Researchers discovered a new type of post-translational modification, called “oligophosphorylation.” Rather than being tagged

1/13 🧵 Today, Bindcraft was published in nature , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views: Cell cell.com/cell/fulltext/…

What is a PhD?

Target RNA recognition drives PIWI∗ complex assembly for transposon silencing cell.com/molecular-cell…

This article suggests that TF binding is determined by the sum of multiple, overlapping binding sites. Thus, competition between paralogous TFs for shared high-affinity binding sites may be influences by flanking nucleotides from overlapping, lower-affinity binding sites. 🧵

Why has it taken over 50 years to publish a study that examined the total lifetime exposure to ‘safe’ glyphosate levels to which most people are subjected and find multiple types of cancer? regenerationinternational.org/2025/06/24/the…

Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance. The regulation of most proteins is dominated by different regulatory mechanisms across cell types. Gratifyingly, this complex regulation defines simple rules ⬇️

#miRNAs bbc.co.uk/news/articles/…

A big moment for biomedical research publishing: - HHMI preprint mandate. Starting January 1, 2026, Howard Hughes Medical Institute (HHMI) labs will be required to publish all original research articles that represent major contributions from their laboratories as both

We are proud to share a paradigm-shifting publication from Westlake University in the journal Science Magazine . The study, led by Prof. Xiang-Dong Fu, reveals a fundamental mechanism of gene expression: how cells accurately identify correct splice sites during transcription.

Now online! Single-cell nascent transcription reveals sparse genome usage and plasticity dlvr.it/TNJwXP

biologists continue to mistake single-cell technical sampling noise for meaningful cellular heterogeneity. the apparent sparsity of single-cell data is due largely to technical artifacts like transcript capture and sequencing depth--if there are hundreds of thousands of

Our RAEFISH spatial transcriptomics technology is now published in Cell Cell! RAEFISH enables sequencing-free whole genome spatial transcriptomics at single molecule resolution. This work represents the first time that transcripts from more than 23,000 genes were

Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. authors.elsevier.com/c/1lt5I3vVUPVb…

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! science.org/doi/10.1126/sc…

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story led by Frederick Rehfeld revealing that the answer is YES! Read on to find out how. biorxiv.org/content/10.110…

Dysregulation of AGO2-miRNA dynamics underlies the AGO2-associated Lessel–Kreienkamp syndrome | Nucleic Acids Research | Oxford Academic academic.oup.com/nar/article/53…