A Phase 2 Randomized Trial of Survodutide in MASH and Fibrosis nejm.org/doi/full/10.10…

Tirzepatide puts up solid #MASH data with ~50% of subjects achieiving improvement in at least one #fibrosis stage nejm.org/doi/full/10.10…

Exciting new technology together with Mahla Poudineh for monitoring lactate and glucose in vivo using aptamers. Congrats to Elaheh Bakhshandeh and Hanjia Zhang. Great collaboration with Juewen Liu and Jonathan Schertzer (SchertzerLab). onlinelibrary.wiley.com/doi/10.1002/ad… McMaster University University of Waterloo NSERC / CRSNG

New in the #AJPEndoMetab April issue! Effects of #exogenous lactate on #lipid, #protein, and #glucose metabolism—a randomized crossover trial in healthy males Mette G. B. Pedersen, et al. ow.ly/svGJ50SmivA #EnergyExpenditure

Symbolic of chronic underfunding of science and research.

A new Recombinant adeno-associated virus (rAAV) vector for selective targeting of brown adipose tissue Molecular Metabolism sciencedirect.com/science/articl…

#Diet analyses from US cohorts suggest haem iron intake but not non-haem iron is associated with a higher #T2D risk Nature Metabolism nature.com/articles/s4225…

Supplementation of extracellular and peripheral Acyl CoA Binding Protein (ACBP/DBI) promotes food intake and might constitute a viable strategy for treating #anorexia Science Translational Medicine science.org/doi/10.1126/sc…

🤯Wow! Another outstanding study from Ana Domingos showing that peripheral vs central NPY has opposite effect on body weight independently of food intake!! nature.com/articles/s4158…

Special issue on #tech and #diabetes published in Diabetologia. Please retweet diabetologia-journal.org/collections/di…

Stress-sensitive neural circuits change the gut microbiome via duodenal glands cell.com/cell/fulltext/…

Some thoughts on: Postbiotics and metabolism academic.oup.com/edrv/article/d…

Some thoughts on: Intermittent fasting immunity and metabolism cell.com/trends/endocri…

Metabolic disease alters the adaptation to intermittent fasting in mice journals.physiology.org/doi/abs/10.115…

Kinase inhibitors alter blood glucose, insulin, and inflammation in mice journals.physiology.org/doi/abs/10.115…

It's important to closely monitor certain medications to ensure they work properly & safely. Our new publication in Advanced Science introduces a new #WearableAptalyzer application for monitoring vancomycin & gentamicin, key antibiotics for treating severe infection. Wiley

Commensal consortia decolonize Enterobacteriaceae via ecological control nature.com/articles/s4158…

BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis cell.com/cell/fulltext/…

IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis cell.com/cell-metabolis…

Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis nature.com/articles/s4225…