Light/dark matters: Have a look at this very insightful work from Daniele Mattei, PhD and co-authors that reveals important alterations in microglia between the wake and sleep phases!

Postdocs are critical to the research work of Icahn School of Medicine at Mount Sinai. They’ve had no raise since before the pandemic. After 14 months of bargaining now they have been forced to go out on strike. I stand strongly in solidarity with Sinai Postdoctoral Organizing Committee-UAW.

medrxiv.org/content/10.110……I am excited to share with you our new #medRxiv preprint, where we show differences in #RNAediting between the living and postmortem human brain. These alterations are potentially driven by inflammation and hypoxic conditions during organismal death.

The Living Brain Project, led by Drs. Alexander Charney and Brian Kopell, has produced a large publicly available resource for studying the "living brain," providing researchers with a window into how our brains function at the most basic molecular level: mshs.co/3QNslKg.

Our new article on A-to-I editing reveals differences in editing levels between postmortem and living brain tissues. Led by Miguel Rodríguez de los Santos & the Living Brain Project team: nature.com/articles/s4146… #RNAediting #ADAR #RNA Mount Sinai Genetics Icahn School of Medicine at Mount Sinai Mount Sinai Psychiatry Friedman Brain Institute

A Mount Sinai study reveals major differences in #RNA editing between postmortem and living prefrontal cortex brain tissues, shaping the development of diagnostics and therapies for #brain diseases: mshs.co/3RRdChU Michael S. Breen Miguel Rodríguez de los Santos alex charney Center for Neuromodulation

EXCITING NEW STUDY by Icahn School of Medicine at Mount Sinai's Miguel Rodríguez de los Santos Panos Roussos alex charney Michael S. Breen, et al. shows major differences in RNA editing btwn living & postmortem human brains! Discovery may play significant role in treating brain diseases Nature Communications nature.com/articles/s4146…

Microglia cells adapt to the circadian rhythm by going through transcriptional, proteomic and phenotypic alterations. Mattei et al. convincingly suggest: Mind the time, when you study #Microglia!!Wonderful work Daniele Mattei, PhD 👏

Our recent work with Seaver Autism Center evaluating peripheral transcriptomic effects of #ketamine in children with #ADNP syndrome. Mount Sinai Psychiatry Mount Sinai Genetics Friedman Brain Institute nature.com/articles/s4139…