:g V &Gggr4r Gg V

Pull on normally expressed mRNA and robustly identify bound #RBP and #miRNA? In living, wt animals? Yep, that's what they managed to do. Oh, and reprogramming mirna targeting between mirna family members as a very nice validation experiment too... So impressed!

The latest work from the lab is out today in Cell - a team led by Ana Fiszbein found that splicing feeds back on transcription, as new exons arising through evolution stimulate the usage of new transcription start sites. Congrats to the authors! cell.com/cell/fulltext/…

Fantastic work by my friend Stefanie Grosswendt et al. (MPI for Molecular Genetics, Meissner lab) on WT/mut cell states in early mouse embryos - revealing crucial role of PRC2. Congrats for this impressive paper & your own lab MDC-BIMSB . Proud and excited to see what you will do next. You rock!

“Parallel genetics of regulatory sequences using scalable genome editing in vivo” with bora Altuna Akalin Nikolaus Rajewsky MDC-BIMSB Max Delbrück Center cell.com/cell-reports/f… here is the story: 👇👇👇 1/13

How to efficiently analyse & process large-scale spatial transcriptomics data from different techs? We've developed Spacemake that does this and much more biorxiv.org/content/10.110…

If you're interested in spatial transcriptomics, do have a look at spacemake. It can make your life easier :)

Cells live and interact in 3D tissues but pathology and spatial omics typically rely on 2D sections... Excited to share our latest efforts in Nikolaus Rajewsky lab to generate a 3D, multimodal atlas of a human tumor! Find out what we learned: video + 🧵! 🔗 bit.ly/3D_lung_cancer

I continue to be amazed by these data and analyses! Fantastico!

1/6 📣 Postdoc and PhD positions in my lab! I’m looking for talented postdocs & PhD students passionate about gene regulation and RNA metabolism in neurons & neurodevelopment to join my group Human Technopole humantechnopole.it/en/research-gr…

I 💕 this: important biological information extracted from "noise". Power of sc + statistics + Dominic's Lab ;-)

Dies! Wählen Leute #noafd eigentlich direkt *wegen* der Menschenverachtung, oder weil sie denken "bin ja *normal* und kein Ausländer/divers/linksgrüner/etc" und "Hauptsache Benzin/Atomkraft/Frauen an den Herd/kein gendersternchen/etc"? Ich weiß nicht was ich schlimmer finden soll

Viral hijacking of cell machinery always amazes! Here, highly relevant for SARS CoV2 Also, nucleotide-linked protein primes viral replication 🤯

Mireya is awesome! If you want to work in Barcelona, go and apply!

"Harnessing AI to simplify data analysis in Biology". AI-generated summary for our AI assisted data analysis paper 😆 Listen here: sciencecast.org/casts/hwf80q2k…

here it is- read about 3D virtual tissue blocks, metastasis-lymph node boundaries and unlocking molecular mechanisms in 3D. biggest congratz to the entire team. Open-ST: High-resolution spatial transcriptomics in 3D | bioRxiv biorxiv.org/content/10.110…

You call it the systems biology department, but to me it’ll always be

How every wetlab experiment looks to me. Mad respect for experimentalists

Greatly enjoying this clear, concise and original paper from the Peter Sudmant lab! I had no idea you could learn so much from mitochondrial genetics. Big thanks to Isabel Serrano et al. for their amazing work. nature.com/articles/s4155…

Another excellent reason to get off the fossil juice. In the meantime: mad respect for Anna Muzychuk who chooses spine over money. Inspiring!