The faulty ADA2 protein interacts with the healthy ADA2, impairing enzyme function and/or secretion leading to disease. This has implications for diagnosis, and underscores that attenuated forms of ADA2 deficiency can present in adulthood with various disease manifestations 🚩

HIV affects the mitochondria of immune cells: HIV patients have 4x smaller mitochondria in NK cells, which are important in fighting viruses and cancer cells. There's a clear difference between both. mitochondria in red and the cell membrane in green pmc.ncbi.nlm.nih.gov/articles/PMC11…

HHV-6A and HHV-6B both infect NK Cells and impair NK Cell killing but through different molecular pathways. mdpi.com/1999-4915/9/12…

Bless this lady. 🫂 Unpredictability she’s fallen severely allergic to products and food. Doctors are telling her she’s developed lupus, but is it lupus that is the true nature of her symptoms or is it in fact the multiple #Covid infections she’s been exposed to?! Maybe #MCAS

Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis. elifesciences.org/articles/90375…

When I was a medical student, I vividly recall taking care of very very sick patients with acute pancreatitis in the ICU. Remarkable to see how APOC3 inhibition (here, olezarsen) is now shown to be a highly effective therapy for severe hypertriglyceridemia, esp among those with

High TIGIT expression suppresses HIF-1α expression by inhibiting the PI3K/AKT/ mTORC1 or ERK signaling pathway, thereby impairing glycolysis and ultimately reducing NK cell migration CDD press 🇨🇳 nature.com/articles/s4141…

New Research: Investigating the role of Akkermansia muciniphila Akk11 in modulating obesity and intestinal dysbiosis: a comparative study of live and pasteurized treatments frontiersin.org/articles/10.33… #FrontiersIn #Microbiology

Cancer's Own Machinery 'Hijacked' to Spark Anti-Tumor Response The immune-activating molecule cGAMP reacts to the presence of dsDNA in the cells’ cytoplasm, causing the #immunesystem to fight the tumor Natalie Artzi MassGeneral News #melanoma #tumors hubs.li/Q03SgL_k0

Shyness starts deep in the brain: A new fMRI study links lower neural synchrony in the cerebellum to social inhibition—mediated by the brain’s threat-monitoring system (BIS), not reward-seeking. neurosciencenews.com/shyness-cerebe…

ME/CFS virus study: medrxiv.org/content/10.110…. Varicella-Zoster Virus (VZV) found in 6 of 17 patients, none in controls. Limitations: only plasma and DNA tested, small sample size, may miss latent/reactivating viruses.

After leukemia treatments failed, Alyssa Tapley, at age 13, was told she would die. Then, doctors tried an experimental gene-edited therapy. She became the first human to try the treatment made possible by U.S. federal funding. Now 16, she’s cancer-free and planning her future.

A study on natural killer cell immunoglobulin-like receptor (KIR) alleles shows that inhibitory KIRs alter NK cell function, leading to reduced NK cell cytotoxicity, and are associated with myalgic encephalomyelitis (ME). sciencedirect.com/science/articl…

A new brain-to-text system can now verbalize what a person is seeing or imagining. The findings show that our thoughts can be decoded into sentences even before we put them into words. dlvr.it/TPBBvn

A new UCP1-independent thermogenic mechanism in peroxisomes dlvr.it/TPBD7G

New Research: Proteomic analysis of exosomes from Brucella abortus-infected macrophages reveals possible mechanisms of immune evasion and host modulation frontiersin.org/articles/10.33… #FrontiersIn #Immunology

Review Journal of Human Immunity Casanova Lab The seven enigmas of SARS-CoV-2: From the past to the future rupress.org/jhi/article/1/…

A systematic literature review of CVID reveals pervasive detrimental noninfectious manifestations Journal of Human Immunity rupress.org/jhi/article/2/…

Viagra could bring back your hearing.A Common Drug Might Help Reverse Genetic Hearing Loss, Scientists Say scitechdaily.com/a-common-drug-…

"This discovery could completely change how we think about the development, and consequently the treatment, of [cancer] in people who have a health condition that compromises immune function." NIAID News sciencealert.com/scientists-dis…