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#Epigenetic #reprogramming using antisense oligonucleotides reduced epigenetic age and prevented the expression of SASP genes. They only tested this mechanism in cells from humans with progeria and in a mouse model of accelerated aging. science.org/doi/abs/10.112…

Be your model organism x.com/Solocuriosos_1…

I had the opportunity to interview Aubrey de Grey, a pioneer in the field of #longevity. We discussed a range of subjects, including the ongoing projects to repair #aging at the new Longevity Escape Velocity Foundation. youtu.be/KEdRTzl2DgY

I support the Mensarius Oath of ethical investing. lnkd.in/d9rJNAqb

I recently had the opportunity to interview Dr. Nir Barzilai. Among various subjects, we discussed the mission of the Healthy Longevity Medicine Society and the Longevity Biotechnology Association. We also reviewed some biological…lnkd.in/e4XrWgud lnkd.in/ezndnb86

had the opportunity to interview Dr. Nir Barzilai. Among various subjects, we discussed the missions of the Healthy Longevity Medicine Society and the Longevity Biotechnology Association. We also reviewed some biological processes…lnkd.in/ePHHrQKe lnkd.in/ezndnb86

I had the opportunity to interview Dr. Nir Barzilai. Among various subjects, we discussed the missions of the Healthy Longevity Medicine Society and the Longevity Biotechnology Association. We also reviewed some biological processes that promote longevity…lnkd.in/eun5W_2H

I recently had the opportunity to interview Dr. Nir Barzilai. Among various topics, we discussed the mission of the Healthy Longevity Medicine Society and the Longevity Biotechnology Association. We also reviewed some biological…lnkd.in/e7vnTwzK lnkd.in/ezndnb86

A new study in Nature reported that transcription becomes faster and less accurate with age (Debès, Nature, 2023). If you found this study interesting, you might also want to check out these recent publications that have studied…lnkd.in/ehVarS4w lnkd.in/ehGnYpTg

Throwback Thursday In 1935, Clive McCay and his team at Cornell University reported for the first time that reducing caloric intake without causing malnutrition increases the lifespan of a mammal. Note that McCay's main interest was to examine the effec…lnkd.in/eRfKmMce

This new article relates to garb-aging and is an excellent example of how the hallmarks of #aging are interdependent. Jin J, Nature Aging, 2023 1- #Autophagy fails with age, compromising #proteostasis and organelle turnover.  2-…lnkd.in/e3Fm9KpW lnkd.in/eD_PjpaH

How are #biotech companies treating #muscle loss and atrophy? Initially, I selected industry-funded interventional studies focused on muscular atrophies in adults and older adults registered in NIH's ClinicalTrials.gov in the following stages: not y…lnkd.in/eFNt7b-8

Imagine a #gpt for protein design. This group created a "protein language model" to improve the affinity of #antibodies against coronavirus, ebolavirus, and influenza A virus. Language-model-guided affinity maturation involves tra…lnkd.in/e3wt3p-T lnkd.in/e3NRPpAv

This new study describes a synthetic gene network oscillator that slows down #aging in yeast cells. The team created a gene oscillator that alternated between two mutually exclusive cellular aging pathways: #nucleolar decay and #m…lnkd.in/e6qPT3_H lnkd.in/er3dRDCP

The first draft of the human #pangenome reference was published in this week's Nature. lnkd.in/epfH9Q-t The first draft of the human #genome was published in 2001. lnkd.in/e82-DQc6 The human pangenome reference aims to provide a more accur…lnkd.in/e2Ac4dQ5

#Microglia produce a subset of large extracellular vesicles that inhibit protein aggregation in #alzheimers disease. Microglial #secretome-derived products may be harnessed as a therapeutic option for neurodegenerative diseases. …lnkd.in/dvMKBnuH lnkd.in/dp54zUR2

Check out the 12 most disruptive technologies to improve healthcare, according to faculty at the Mass General Brigham network. More than half of these innovations directly address an unmet need for age-related chronic diseases.…lnkd.in/eFGACp-X lnkd.in/epsjWhvm

Network science explores the process by which complex systems emerge from interactions among their components. Complex systems may build themselves following some universal principles. A scale-free network tends to grow preferent…lnkd.in/ehvFrXg8 lnkd.in/ePD2cmgY

A new Cell Press paper exploring how cellular #senescence can help tissue maintenance and repair. In a marine invertebrate related to anemones, senescent cells play a role in promoting the de-differentiation of neighboring cells.…lnkd.in/e8jSKw8R lnkd.in/eud7V6qq

Injection of recombinant α-Klotho improved the working memory of naturally aged rhesus monkeys. Castner SA, et al, Nature Aging, 2023 lnkd.in/eeebpaM8 The protective effect of Klotho in this setting is indirect and mediated by unidentified messen…lnkd.in/epYUFqq2