C-Terminal Decarboxylation of Proline-Derived Building Blocks for Protein-Binding Peptides (Hans-Guenther Schmalz and co-workers). #OpenAccess thanks to #ProjektDEAL. Pascal Markus Engelhardt RELOC onlinelibrary.wiley.com/doi/10.1002/ch…

Amazing recent work on presudoprolines forming polyproline-2 helix by Greg Chaume and the team! Another one polyproline-2 crystal structure to the existing collection. doi.org/10.1039/D4CC02…

Thank you Marina Rubini for the cute postcard from Nagoya, Japan! I hope you enjoyed the CPS Meeting you attended and the view of mount Fuji 🗻 I really appreciate it. It almost feels like I can travel again 😁

Our dedicated review on the use of proline analogues in drug design focusing on the past 15 years of development, and containing suggestions for the future. With Pavel Mykhailiuk Chem 🇺🇦 ASAP article in #JMedChem Check it out, it's really interesting! pubs.acs.org/doi/10.1021/ac…

'Widespread Misinterpretation of pKa Terminology for Zwitterionic Compounds and Its Consequences' from Journal of Chemical Information and Modeling (JCIM & JCTC Journals) is currently free to read as an #ACSEditorsChoice. 📖 Access the full article: go.acs.org/bT5

New spirocyclic proline analogues via a robust synthesis approach. doi.org/10.1021/acs.jo…

A deep dive into the biochemistry of azetidine-2-carboxylic acid aimed to reveal toxic effects of this noncoded proline analogue on humans and other species. It's a little funny to see how much more intensively this molecule was researched back in the past doi.org/10.1016/j.tox.…

Here is a nice new article on fluoroproline labelling of huntingtin protein and subsequent 19F NMR: doi.org/10.1002/chem.2… As we speculated in our Chem Rev article, this type of labelling could make sense in proline-rich or polyproline domains, which is the case here.

Really good article published few months ago about the choice of linker for drug macrocyclization. Many clever ideas. doi.org/10.1021/acs.jm…

I got a couple of new postcards from Genova and Berlin. Thank you for the Christmas cheer, Lars! Happy 2025, everyone! I hope for a better year for all of you. Let your efforts pay off this year, my dear friends! 🍾🥂🎄🥳

I'm not a computational chemists, but would like to thank Prof Karplus for his work on rotation around peptidyl-prolyl amide bond, where they identified the major rotation pathway, and introduced the rotation transition state nomenclature. Merci!

The importance role of central proline to the antimicrobial potency and selectivity of indolicidin doi.org/10.1007/s00203…

Aromatic caps at the termini promote stability to triple helix in collagen mimics with just 4-6 GPO repeats doi.org/10.1021/acs.bi…

Few interesting heteroatomic proline analogues in collagen mimetics. Seems that 5-oxaproline is well tolerated and accelerates the triple helical assembly. Great work! doi.org/10.1039/D5OB00…

A fold stabilizing effect of a proline analogue on a 36 residues miniprotein doi.org/10.1038/s42004…

Another amazing work from the group of JC Horng, unveiling the effects of cation-pi interactions in the assembly of the collagen triplex doi.org/10.1021/acs.jp…

A whole panel of 5-spirocyclic proline analogues prepared by colleagues from Enamine doi.org/10.1039/D4OB01…

Just learned that chronic Staph. aureus readjusts its metabolism to feed on proline from collagen deposits. Mindblowing! doi.org/10.1038/s41564…

Really impressive review article on how to improve substance's solubility AND permeability at the same time, the trait combination that the authors called Aufheben. Great summary of strategies and examples from contemporary drug design! Open access doi.org/10.1021/acs.jm…

Very much enjoyed reading the newest review from Ned, Hamid and Huy on genetic code engineering. A summary of efforts, pitfalls and challenges. doi.org/10.1002/cctc.2…