Excited to share major progress on next generation of AlphaFold! Together with Isomorphic Labs, we’ve significantly advanced accuracy & expanded coverage beyond proteins to other key biomolecular classes. Continuing to accelerate science at digital speed dpmd.ai/x-alphafold-pr…

Happy Halloween everyone!!! Thanks Tamara Mikeladze-Dvali for organizing!!! Traditional pumpkin carving together with MokranjacLab and Böttger labs! 🎃

mtDNA heteroplasmy dynamics are so complex, even paradoxical. To understand why, we combined precise mtDNA editing w/a new method SCI-LITE. In dividing cells, selection (not drift) acts on cell (not intracellular) fitness to shape population heteroplasmy. rdcu.be/dFDCY

Awesome fun activity at the retreat with the The Martin Ott lab at Tjärnö Marine Station 🔬🪸🪼🦀🦭

Just back from a wonderful retreat with the OsmanLab in Tjärnö on the Swedish west coast Göteborgs Marinbiologiska Laboratorium. Three days of scientific discussions around mitochondrial gene expression and maintenance, beautiful scenery and lots of fun. Thanks to everybody for the good times!!

Just wrapped up an amazing retreat at Schloss Ringberg🤩! With fantastic guest speakers/lab alumni, we enjoyed discussing all our exciting projects, hiking, and playing games in this cosy place🍻☀️! #LabLife #scienceretreat #mitochondria #researchlife #science

🚀Excited to share our latest paper, where we explore dynamic changes in mtDNA heteroplasmy in living cells! Discover how asymmetric partitioning and mitochondrial dynamics drive mtDNA variant segregation! 🔬embopress.org/doi/full/10.10… #Mitochondria #microscopy #microfluidics #mtDNA

It was an absolute pleasure to collaborate on this, fantastic work lead by Rodaria Roussou. I'm very happy to see that our #BioimageAnalysis software #CellACDC was useful to analyse these fantastic images Kurt Schmoller

Real-time assessment of yeast heteroplasmy dynamics at the single-cell level: Asymmetric partitioning during cell division & limited mitochondrial fusion/fission frequencies drive mtDNA variant segregation OsmanLab Universität München embopress.org/doi/full/10.10…

Introducing a resource of mtDNA copy number (mtCN) across ~10k human donor-tissues (GTEx), 20 murine tissues, and 173 cancer cell lines. Insights emerge by integrating mtCN w/other large-scale measures, e.g., DepMap cells w/high mtCN resist loss of GPX4. pnas.org/doi/10.1073/pn…

Grateful to everyone who contributed and beyond excited to share my work with you!

Glad to share this little piece referring to last paper published in nature by Prashar et al. Selective degradation of mitochondrial inner membrane through direct transfer to lysosomes Nature News & Views Andreas Reichert ReichertLab nature.com/articles/d4158…

Disordered regions in the IRE1α ER lumenal domain form condensates in vitro and mediate its stress-induced clustering and signaling in cells Elif Karagöz @gekaragoz Max Perutz Labs Vienna and coworkers embopress.org/doi/full/10.10…

Huge thanks to Anjana Badrinarayanan and Nitish Dua for spotlighting our work in The EMBO Journal ! 🙏🧬 Check out the full article here 🚀🔬 embopress.org/doi/full/10.10… #mtDNA #mitochondria

It is not trivial to make the right amount of histones in different nutrients, when #cellsize, growth rate, and S-phase duration change. Still, budding yeast manages by regulating transcription and translation: doi.org/10.1038/s44318… Francesco Padovani

🚨 New segmentation model alert! 🚨🥳 You can finally use InstanSeg in our #BioImageAnalysis software #CellACDC! InstanSeg is a fast and multi-channel cell segmentation model by Pete Bankhead, Thibaut Goldsborough, & co. The multi-channel ability is very interesting!

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number biorxiv.org/content/10.110… #biorxiv_cellbio

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on bioRxiv ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: biorxiv.org/content/10.110… #mitochondria #mtDNA