Samuel Akwasi Acheampong now the lab also knows this 🤩

Oooooh shit! Lucky martians dwellers. They get to see that.

Y s!! Are they free....nope, nevermind.

😅😅😅 embrace it.

Bee 🐝 you

At the #ICE2024Kyoto? Curious to know which of the molecular mechanisms driving the amazing stability of the honey bee gut microbiota is hidden behind the question mark? Come to room C-2 on Tuesday 27th at 1:30 PM. (Art collab. with Ramya Ganesan )

Origami Corner #Amazing #ice2024 #ice2024kyoto #YoshinoriShintani #not4sale

日本固有種の昆虫たち #ICE2024 #国際昆虫学会議

Found this (and recreated using Ramya Ganesan bee illustration) on an entomologist's shirt at the #ICE2024 #ICE2024KYOTO about honey bee researchers and enthusiasts and I COULDN'T AGREE MORE!!!

Oh, no! 🤦🏿‍♂️

👀

Excited about molecular motors? Check out our latest preprint exploring the energetics of a molecular motor in its mechanochemical cycle using cryo-EM structures doi.org/10.1101/2024.1…

I’m thrilled to share that the first manuscript of my PhD is now live on bioRxiv 🎉: Compensatory Evolution to DNA Replication Stress is Robust to Nutrient Availability. Let’s dive into what we found and why it matters! 🔍🧵 (1/7) biorxiv.org/content/10.110…

We tackle a standing question in #Evolutionary #CellBiology: How does the environment, particularly nutrient availability, influence evolution following severe cellular disruptions? The interaction between genotype and environment (#GxE) has been long debated. (2/7)

We evolved 48 parallel populations of replication stress mutants for 1,000 generations, under different glucose levels. It turns out glucose starvation alleviates the physiological defects of these mutants—but evolution revealed something even more surprising… ⬇️ (3/7)

Although glucose levels impacted the speed of adaptation, the genetics of adaptation showed remarkable robustness. Recurring mutations drove adaptation, regardless of glucose availability. Essentially, the environment sets the pace but not the path. ⚡️ (4/7)

We uncovered a new player in adaptation to replication stress: the Mediator Complex of RNA pol II. A single amino acid substitution in one subunit proved beneficial, possibly by impacting the transcription of metabolism genes that interact with DNA replication. (5/7)

Our results suggest that compensatory evolution could be more predictable and robust than previously thought—even in environments that alter key physiological aspects of the cell. (6/7)

Robustness in compensatory evolution could extend beyond yeast, potentially improving our understanding of antibiotic resistance, cancer evolution, and more. Predictable adaptation could be a therapeutic target. 🎯💊 (7/7)

I am excited to share the first part of my PhD work, available on bioRxiv Immunology, bioRxiv now! biorxiv.org/content/10.110… Here’s a thread to tell you about our cool work 🤓👉🏾👈🏾