Ceramide Synthase 6 (CerS6) uses a ping-pong reaction mechanism! Found and probed via CryoEM, MD, and MS. Spectacular work by Tomas Pascoa and colleagues from Centre for Medicines Discovery, Boehringer Ingelheim (Boehringer Ingelheim), and University of Zurich biorxiv.org/cgi/content/sh…

"Integrating cellular electron microscopy with multimodal data to explore biology across space and time"🔬👩‍💻🌌⏳ cell.com/cell/fulltext/… Our new review is online Cell. Big thanks to our amazing co-authors @computingCaitie Sven Klumpe Rommie Amaro Wanda Kukulski @EM_STP

(1/n) The 46th Indian Biophysical Society Meeting, jointly organised by TIFR Hyderabad & Univ of Hyderabad, began with three plenary talks about - 'checkpoints' in the cell which prevent D-amino acids from integrating into protein chains (Rajan Sankaranarayanan, CCMB),

If you also haven’t read Kahneman’s “Thinking, Fast and Slow” and don’t want to read a whole book, read his 2003 “Maps of Bounded Rationality” instead. It’s a publication that summarizes the same ideas in his own words.

Fantastic molecular machines!

What's the evidence for Evolution? If you want to give Creationists something to think about, here's my top 10 list of classic discoveries from genomics, biogeography, the fossil record, microbiology, developmental biology, origin of life work and population genetics. 🧵🔽 (1/11)

Thrilled to share our exciting paper on #NINJ1 published in Cell. NINJ1 acts as "🍪cutter" by cutting and releasing membrane disks leading to lytic cell death. doi.org/10.1016/j.cell… Congrats to the amazing team-Prof. Hao Wu Bobby Hollingsworth Jazlyn Borges @LabSteinberg

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Regular reminder. As an academic, student, postdoc, or professor, you accept less pay and more stress. It is only worth doing if what you do truly matters. Do that high-risk project. Because the boring project does not justify the downsides of academia. For the love of ideas.

"You can change the world as long as you don't care who gets the credit." A brilliant podcast by George Church!

Molecular mechanism of the flotillin complex in membrane microdomain organization biorxiv.org/cgi/content/sh… #bioRxiv

"Join us! our department is very supportive" x.com/visualfeastwan…

Grateful to all of you for making this journey worthwhile! 🎉

Excellent tips 🙌

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Happy to see this work now out as a preprint🎆 ...Cheers to the team for all the hard work and effort Sakshi Shambhavi Arnab Chakraborty Bapin Kumar Panda Nikita Shukla Santhosh Priyadarshan Kinatukara Biswajit Pal Thanks to 🎩 Sankaranarayanan Rajan Siddhesh Kamat

Please subscribe to the Night Science Podcast where in each episode, two scientists – Martin Lercher & me – talk with a colleague about their creative process. Apple: podcasts.apple.com/us/podcast/nig… Spotify: open.spotify.com/show/6berzd2rX… Buzzsprout: buzzsprout.com/1744020/episod… The Night Science Podcast

We are back again!✌️ Our latest work in @elife reveals the long-lost evolutionary origin of the DAG-PKC signaling pathway regulated by Dip2! Shoutout to the team behind this breakthrough!👏Sakshi Shambhavi Sudipta Mondal, PhD Siddhesh Kamat Sankaranarayanan Rajan CCMB shorturl.at/cxdKI

You want to start tomography? Solve structures inside cells? Reach Nyquist😳? We have a website for you! tomoguide.github.io You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software! Hope it will be useful !