'Tau protein profiling in #tauopathies: a human brain study' Juan Lantero-Rodriguez & Elena Camporesi Laia Montoliu-Gaya Johan Gobom...Kaj Blennow & Gunnar Brinkmalm Uni of Gothenburg Sahlgrenska Academy bit.ly/3YaBBwp

'Astrocytic #autophagy plasticity modulates Aβ clearance and cognitive function in #AlzheimersDisease' Suhyun Kim, Heejung Chun, Yunha Kim...Junghee Lee, C. Justin Lee, Hoon Ryu KIST #astrocytes #amyloid bit.ly/3WxQTtM

🚨HAPPENING NOW!

Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases …arneurodegeneration.biomedcentral.com/articles/10.11…

'Therapeutic potential of APP antisense #oligonucleotides for #AlzheimersDisease and down syndrome-related Alzheimer’s disease' Srishruthi Thirumalai, Rickie Patani Rickie Patani Christy Hung PataniLab #amyloid bit.ly/4c76fdi

'#Astrocyte reactivity is associated with tau tangle load and cortical thinning in #AlzheimersDisease' Tengfei Guo Tengfei Guo...Jie Lu & Ying Han #Biomarkers #PlasmaBiomarkers bit.ly/3WUjYA9

We revealed that Plasma A+/T+ showed significant evidence of cortical Aβ deposition, tau aggregation, hippocampal atrophy, and cortical thinning using plasma biomarkers in a Chinese aging cohort, and further demonstrated the critical role of astrocyte reactivity in AD progression

'Single-cell peripheral immunoprofiling of #lewybody and #Parkinsons disease in a multi-site cohort' Thanaphong Phongpreecha, Kavita Mathi, Brenna Cholerton...Thomas J. Montine Stanford University bit.ly/3SvCegv

We are excited to announce Dr. Aaron D. Gitler Stanford University as our next ISMND Science Webinar speaker! Title: Expanding mechanisms and therapeutic targets for neurodegenerative disease August 15, 2024 1pm-2pm (ET) Host: Philip Wong, Ph.D. Register: bit.ly/4fpzfjD

'Network #proteomics of the #LewyBodyDementia brain reveals presynaptic signatures distinct from #AlzheimersDisease' Anantharaman Shantaraman Eric Dammer Obiadada Ugochukwu....Nick Seyfried Lenora Higginbotham Emory School of Medicine #biomarkers …arneurodegeneration.biomedcentral.com/articles/10.11…

'Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with #ProgressiveSupranuclearPalsy' Hui Wang Timothy S Chang...Dennis W. Dickson Günter Höglinger Gerard Schellenberg Geschwind Lab @ UCLA Wan-Ping Lee #APOE bit.ly/4fQqqPK

So interesting, ApoE2 as a risk variant for PSP..

🚨News-and-views review of our recent lysophagy paper is now available #OpenAccess in Autophagy! 🧫🧬Check it out if you are interested in lysosomal dysfunction and AMD 👁️ tandfonline.com/doi/full/10.10… Patricia Boya SEFAGIA (Sociedad Española de Autofagia) Women in Autophagy Molecular Neurodegeneration CIB Margarita Salas (CSIC)

🔎 Spotted in Molecular Neurodegeneration! Researchers from DZNE Research Center, among others, used DSHB's anti-synaptotagmin-2 [ZNP-1] mAb in a study on endogenous TDP-43 and how it leads to ALS-like early-stage metabolic dysfunction. 📄 tinyurl.com/2p847avw 🧫 dshb.biology.uiowa.edu/znp-1

'Pathological characteristics of #axons and alterations of #proteomic and #lipidomic profiles in midbrain #dopaminergic #neurodegeneration induced by WDR45-deficiency' Panpan Wang, Yaping Shao, Murad Al-Nusaif... Weidong Le #autophagy bit.ly/3T1Y77a

We are thrilled to announce Dr. Eleanor Drummond Eleanor Drummond University of Sydney as our next ISMND Science webinar speaker! Title: Using #proteomics to explore #AlzheimersDisease pathogenesis September 19, 2024 9am-10am (EST) Host: Lucy Job Molecular Neurodegeneration Register: bit.ly/3X3L4mS

'Identification of a specific #APOE transcript and functional elements associated with #AlzheimersDisease' Qiang Chen...Sudha Seshadri Sudha Seshadri, MD Liang Ma Liang Ma UT Health San Antonio bit.ly/3TaElXj

Dalian Medical University researchers uncovered the molecular mechanisms underlying the contribution of WD repeat domain 45 (WDR45) deficiency to #axonal degeneration. 📚 Read about their findings in Molecular Neurodegeneration! bit.ly/3MmVPMt

I am excited that our #APOE work has been published on Molecular Neurodegeneration

'Regional desynchronization of #microglial activity is associated with cognitive decline in #AlzheimersDisease' Artem Zatcepin, Johannes Gnörich, Boris-Stephan Rauchmann... Matthias Brendel MatthiasBrendel Universität München DZNE Research Center Munich Cluster for Systems Neurology (SyNergy) bit.ly/4ecTMXa