New study by the Vandenberghe and Verstreken Lab on the interplay between alpha-synuclein and mitophagy, in vivo and in human neurons. Elevated α-synuclein levels inhibit mitophagic flux pubmed.ncbi.nlm.nih.gov/38594264/

A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy rupress.org/jcb/article/22…

Remember Nucleoid-phagy? PrudentLab Luis Carlos Tábara Rodríguez

I am honoured to coauthor one of my favourite papers of all times when it comes to #mitochondria #ageing and #senescence! cell.com/developmental-… So things are not always as we dogmatically assume. Mitochondrial and "-phagy" dysfunctions are reported to occur with ageing...

⚠️New issue of #mitophagy news 🪫🔋🗑️ Lots of papers, sorted by yours truly with the help of Bims: Biomed News biomed.news/bims-tofagi See below for highlights in the following categories: 1) Cellular & Molecular mechanisms 2) Pathophysiological relevance 3) Experimental tools

1) Cellular & Molecular mechanisms A new mechanisms of selective removal of mitochondrial material (nucleoids) nature.com/articles/s4155…

1) Cellular & Molecular mechanisms Another mechanism of selective removal, this time in the quality control of cristae MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels cell.com/cell/fulltext/…

1) Cellular & Molecular mechanisms TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery pubmed.ncbi.nlm.nih.gov/38814780/ Identification of two novel negative regulators of PINK1- dependent mitophagy nature.com/articles/s4159…

2) Pathophysiological relevance Basal mitophagy in primary cells is PINK1-dependent, is suppressed and controls ageing phenotypes cell.com/developmental-…

2) Pathophysiological relevance Olfaction regulates peripheral mitophagy and mitochondrial function science.org/doi/10.1126/sc…

2) Pathophysiological relevanc Burkholderia pseudomallei BipD modulates host mitophagy to evade killing nature.com/articles/s4146…

3) Experimental tools A novel photoreversible protein translocation tool demonstrates that 1 hour of mitochondrial PINK1-relocation is necessary for Parkin recruitment nature.com/articles/s4158…

3) Experimental tools A novel mitophagy inducer that selectively reduces organelle quantity bpspubs.onlinelibrary.wiley.com/doi/10.1111/bp…

Takami Sho, Li Yu et al. Tsinghua University unveil migratory autolysosome disposal, a response to #lysosome damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring #autophagy machinery, SNARE proteins, and cell #migration. hubs.la/Q02Rwbhg0

Hey #myotwitter enjoy this week’s selection of papers on skeletal muscle, aging, and exercise. 👇 biomed.news/bims-moremu/20… Featuring work from @BowermanNMD The Arany lab @VIKorolchuk

Good Sunday Mitofriends, don't miss this selection of papers related to Mitochondrial Medicine presorted by Bims: Biomed News biomed.news/bims-mitmed/20… biomed.news/bims-mitmed/20… CAPTION: Molecular mechanisms of mitochondrial dynamics

Please have a look at our recent review on mito-dynamics!

Targeting organ-specific mitochondrial dysfunction to improve biological aging; sciencedirect.com/science/articl…

New paper out! #AMPK regulates #ULK1 to balance #mitophagy of functional vs dysfunctional mitochondria in Molecular Cell. Great work from authors, especially Marianna Longo Aniketh Bishnu and collaborators @Kei_Sakamoto Carol MacKintosh. See it here: tinyurl.com/AMPK-ULK

To understand aging, we need to reconcile the sub-cellular molecular hallmarks of aging with whole-body aging phenotypes