DNA to RNA real-time speed. Gene Transcription at real-time speed. Transcription is the first step in gene expression.

An MRI of what it looks like when you rub your eyes: #biology by D. Gatinel

Human ribosomes decode messenger RNA 10 times slower than bacterial ribosomes—but do so more accurately. Explore how St. Jude scientists made this discovery. bit.ly/3zxa9v8 Scott C Blanchard @nature #cryoEM

Now #OA nature: combining #cryoEM and #smFRET to examine decoding by human #ribosome, Scott C Blanchard reveals important differences from bacterial ribosome and mechanisms of action of several translation inhibitors. nature.com/articles/s4158…

See also Research Briefing here: nature.com/articles/d4158… Congrats Scott C Blanchard MikaelScience @ERundlet S.Kundhavai Natchiar and all authors!

Mechanism of messenger-RNA decoding in humans illuminated nature.com/articles/d4158…

Is mRNA decoding in humans structurally and kinetically distinct from bacteria? news-medical.net/news/20230407/… nature St. Jude Research #mRNA #bacteria #molecularbiology #research #bacteria #microbiology #cells #news

Proud to be involved in this work. Please have a look. High res.80S ribosome, many states, interesting story. Scott C Blanchard alexmag S.Kundhavai Natchiar nature.com/articles/s4158…

Happy to anounce our paper published today ⁦nature⁩ - a tour-de-force in tRNA biology. We developed suppressor tRNAs with high efficieny in correcting PTCs. For a disease protein we crossed a disease threshold of correction. #cftr #uhh nature.com/articles/s4158…

Very soon and thanks to one an only JM de la Rosa Trevin an integrated solution for CryoEM facility management and on-the-fly processing with Cryolo/ctfffind/Relion ! And free!!! 👇🏽 Look at these gorgeous ribosome from Scott C Blanchard !

We suffered two problems on our Krios/Arctica instruments related to a pressure gauge called PPal. Here a picture of the faulty PPal from the Arctica. But then...what is a PPal and how it measures pressure? These two questions kept me busy for a while, a thread to follow 👇

check out our Spotlight Article Trends in Genetics 🔥 hot 🔥 off the press! teamed up with Olivier Duss (EMBL Heidelberg) & Rainer Nikolay (MPI for Molecular Genetics) to cover the recent mRNA decoding ribosome smFRET🤝cryoEM story from Scott C Blanchard open access 👇 authors.elsevier.com/a/1hJjvcQbJ7Wti

In our new Spotlight in Trends in Genetics we are discussing the recent nature paper from Scott C Blanchard about eukaryotic mRNA decoding combining smFRET and cryoEM! Was fun to collaborate with & Matthew L. Kraushar & Rainer Nikolay MPI for Molecular Genetics on this! sciencedirect.com/science/articl…

Our study shows that ribosomal genes—widely used to infer the origin of species—also hold a record of the optimal growth conditions for a given species, making it easier to infer the optimal environment for uncultured or extinct organisms (1/3): academic.oup.com/nar/article/do…

Happy to share that Mathew Gagnon and my lab's joint story of translation inhibition by aminoglycoside Amikacin is now published in Nature Communications 🥳🥳🥳. Superhappy for this collaboration. Fast-kinetics biochemistry and structure together make a very powerful tool afterall 😃

It is out in PNASNews. A massive bioinformatics undertaking by Gemma C Atkinson lab + an insane amount of experiments from my team and numerous collaborators. The first new phage defence system from Lund! Henrik Strahl Arne Elofsson @arneelof.bsky.social Karin Ernits Faculty of Medicine Lund University pnas.org/doi/10.1073/pn…

High resolution Molecular dynamics (MD) of mRNA translation on ribosome

» Ribosome-binding antibiotics increase bacterial longevity and growth efficiency | PNAS pnas.org/doi/abs/10.107…

Out today from the Blanchard lab! An important paper showing that the accuracy of smFRET measurements depends on excitation strength, and how to correct for these issues or bypass them with self-healing dyes. nature.com/articles/s4159…

Excited to share our Annual Reviews in Biophysics article on Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function. Many thanks to all authors for their diligence putting this summary overview together! pubmed.ncbi.nlm.nih.gov/39013028/