A cool web tool for browsing the simulated gene structures from our paper 'Gene structure heterogeneity drives transcription noise within human chromosomes'. 3dgene.igc.ed.ac.uk Here is one of my favourite genes - what's yours?

One new application of the DFCC method for studying nuclear organization. Check out our new story on how RNA Pol II movement during transcription is coordinated over long-range in the context of chromatin dynamics, tandfonline.com/doi/full/10.10…

Our work on chromosome micro-manipulation in living cells is out in Science Magazine! science.org/doi/10.1126/sc… What if you could put your hand 🫳 inside a nucleus, grab a small portion of a chromosome 👌, and see how it reacts when you pull on it? 🤔 … 🧵 1/n

What a fantastic experience so far at the Genome Organisation by SMC Complexes conference! It's been great to present my simulation work on 3D gene structure and transcriptional noise and learn about all the exciting new science of SMC proteins. #BioChemEvent

It's been an awesome week learning and discussing new science at the #EMBOworkshop on Nuclear Structure and Dynamics. Many thanks again to the organisers for giving me the opportunity to speak about our lab's work on HiP-HoP and 3DGene (3dgene.igc.ed.ac.uk)!

We have a new postdoc position available in our collaborative research group. Using molecular biology and imaging techniques to study and understand transcriptional noise. Get in touch if you would like to chat or apply here edin.ac/3VyQJQE

So far, most DNA-loop-extrusion data were taken on naked DNA. But what happens on chromatin in cells where DNA is loaded with many proteins? Will SMC proteins (that are fast but weak motor proteins) get blocked? Or find a way to translocate the roadblock into the extruded loop? /

M. Chiang, A. Hopkins, B. Loewe, M. Cristina Marchetti, D. Marenduzzo, Intercellular Friction and Motility Drive Orientational Order in Cell Monolayers. arXiv [cond-mat.soft] (2023). arxiv.org/abs/2310.20465

We are excited to announce our new manuscript is on bioRxiv edin.ac/3z7hhBH. We use super-resolution imaging, molecular biology and polymer simulations to show that nuclear RNA forms an interconnected network of microgels. Well done everyone!

Super excited to share our latest work looking at mechanisms that contribute to local hexatic and nematic ordering in tissue monolayers! Intercellular friction and motility drive orientational order in cell monolayers | PNAS pnas.org/doi/10.1073/pn…