BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

An extremely precise reason why #MINFLUX changes the game:

Nagendar: Cryo-EM structure of raiA ncRNA from Clostridium reveals a new RNA 3D fold sciencedirect.com/science/articl… Journal of Molecular Biology Thanks SOLARIS Centre for the great microscope facility. 3D model illustration made with 3D Protein Imaging

I’m proud to share the exciting news that all undergraduate students from households earning $75,000 or less will be able to attend any UMass campus tuition-free starting next fall: bostonglobe.com/2024/10/29/met… @umassamherst @umassboston @umassd @umasslowell #umass #highered (1/4)

First paper of our lab today nature by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! EMBL doi.org/10.1038/s41586…

Our latest work is out in nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s4158…

Never seen RNA structures like these before. Congrats to Rachael Kretsch and rest of team biorxiv.org/content/10.110…

Engineering a ribozyme with aminoacyl-tRNA synthetase activity biorxiv.org/content/10.110…

#ncRNA molecules are stranger than you think. We propose that OLE RNA is bacteria's functional mimic of #mTOR. The Das lab at Stanford proposes OLE RNA penetrates cell membranes! They also find that RNAs we called ROOL and GOLLD form 8-membered nanocages. biorxiv.org/content/10.110…

Excited to share my recent article in ⁦The Hindu⁩ for their Building Block series! I explored an important public health issue related to snakebite & antivenom accessibility in India. Why are antivenoms not easily accessible in India? - The Hindu thehindu.com/sci-tech/energ…

Congrats to the Mammoth Biosciences team on achieving efficient muscle editing with the ultracompact #CRISPR nuclease NanoCas, an important breakthrough that paves the way for curing a wide range of genetic diseases! A nice overview from Science Magazine here: science.org/content/articl…

If u think this work is cool, note that it was done by grad students, PDs and staff in academic labs funded by federal tax payer dollars. If no federal funding, a lot less of this kind of research. Use your voice to protect federally funded research which is under attack. Thank u

Biological systems find ingenuous solutions. Almost anything that can happen, happens. Still, I would not have guessed a role of RNA-binding proteins on the cell surface. The Flynn lab are boldly investigating glycoRNAs and following their leads.

I am very happy to announce that we solved the in-virus #cryoEM structure of the #HIV matrix protein. The structure helped us to resolve a long mystery in HIV biology. A🧵1/5 Read more in nature : nature.com/articles/s4158… 🧪

How sturdy are base pairs near the ends of #RNA hairpins? Perhaps not as stable as one might think, esp. when there are bulges near and far. Led by Bou-Nader lab in Nature Communications, we describe complete structures of #HIV #TAR RNA and its dynamic excursions.nature.com/articles/s4146…

How to find fantastic new #RNAs? The J2 antibody is the gold standard to detect, map & enrich dsRNAs. Co-led by Bou-Nader lab, Kevin Juma, Ankur Bothra & Steve Leppla’s lab, we visualize how J2 recognizes dsRNA and define its epitope, specificity & bias. doi.org/10.1101/2025.0….

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the Children's Hospital who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI

Now online! Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement dlvr.it/TLfrWv

MOSAIC large field of view 3D single molecule localization microscopy of mitochondrial outer membranes and nuclear membranes in fixed U2OS cells.