Boom: Stop and go have new meaning in the basal ganglia. For decades, we thought of the basal ganglia in terms of two great circuits the GO (direct) and NO-GO (indirect) pathways. New work from Anne Graybiel and colleagues challenges this view. Fresh evidence shows that stop and

🔥How does GENETIC RISK FOR DEPRESSION affect your brain? 🔥Extraordinary paper, out today [1], examines genetic risk for depression and brain MRI in 50,975 participants pooled from 11 studies within the ENIGMA Major Depressive Disorder Working Group 🔥People with higher genetic

Epic work led by Habib Ganjgahi is out in Nature Medicine... data-driven clustering of MS finds 3 distinct states, early/mild, active, advanced, w/ transition to the advanced state only occuring through the active state... replicated twice! doi.org/10.1038/s41591…

How A.I. documentation of clinic conversations has improved clinician experience, less burnout in >1,400 clinicians at 2 health systems Mass General Brigham and Emory Healthcare jamanetwork.com/journals/jaman…

🔥ATAXIA includes rare, inherited neurodegenerative diseases characterised by progressive deterioration in motor coordination + cognitive function. 🔥Ian Harding has been leading global efforts to pool data + expertise on these disorders + categorize these ataxias by age of

How can DBS to the memory circuit hurt cognition in some patients but improve it in others? New work led by Calvin Howard Center For Brain Circuit Therapeutics suggests it’s due to patient age. Surprise - older patients do better across both PD and AD!

I was fortunate to work with my role model Michael Fox . Thank you for the quality time you created for us, for the big encouragements, for the seemingly small yet powerful daily encouragements, for your consistency, for supporting us in challenging times, your genuine respect for

Check out our new preprint on Streamline Density Normalization (SDNorm)! SDNorm can reduce bundle variability, improve reliability of along-tract microstructure, and provide metrics for automated bundle QC. 📎Paper: biorxiv.org/content/10.110… 📎Code: github.com/wendyfyx/SDNorm

super cool, this used to take forever back when we were making AI simulation games like Republic.

Two flagship papers from the International Brain Laboratory, now out in nature: 🧠 Brain-wide map of neural activity during complex behaviour → doi.org/10.1038/s41586… 🧠  Brain-wide representations of prior information in mouse decision-making → doi.org/10.1038/s41586… +

Most genetic reports label variants as ✅ “pathogenic” or ❌ “benign.” But what patients really want to know is: what are my chances of getting the disease? 🚨 In our new Science study, we used AI + 1.3M patient records to better answer that…

We are looking for a PhD student interested in studying the brain-immune axis, to understand the interaction between the brain and the immune system in ageing and psychiatric disorders. Large-scale brain imaging biobanks and in house collected datasets will be analysed.

Can we fuse adaptive and connectomic DBS? Julian Neumann & I say yes. Out in Nat Rev Neurology: nature.com/articles/s4158… Thread here: shorturl.at/NtPMf

Nature | Single-cell transcriptomic and genomic changes in the ageing human brain Downregulation of short, highly expressed housekeeping genes with age, correlating with increased somatic mutation accumulation. Conversely, longer neuron-specific genes maintain their expression

🔥🔥Excited to announce that I am recruiting PhD students this fall. Our lab uses neuroimaging (MRI) and computational modeling to study the mechanisms of neurodevelopmental disorders, bridging genetic factor, brain circuitry, early life stress, and psychopathology. Please DM me

New Open dataset alert: 🧠 Introducing "Spacetop" – a massive multimodal fMRI dataset that bridges naturalistic and experimental neuroscience! N = 101 x 6 hours each = 606 functional iso-hours combining movies, pain, faces, theory-of-mind and other cognitive tasks! 🧵below

📆 Mark your calendars! Neuromatch Academy 2026 courses are coming! 🧠 #ComputationalNeuroscience & #DeepLearning (6–24 July) 🌍 Computational Tools for #ClimateScience & #NeuroAI (13–24 July) ➡️ Applications open Feb 2026. Sign up for updates: buff.ly/i8h5t6f

High costs motivate efforts to predict spatial transcriptomics from H&E images w/ deep learning. In our recent preprint, we show that noise, sparsity & resolution in ST data impact performance, highlighting the importance of training data quality: biorxiv.org/content/10.110… 🧵1/n

🔥🔥My new lab has a new Postdoc position, exploring how genetic factors and environmental factors (e.g., early life stress) influence brain development, child psychopathology, and neurodevelopmental disorders (e.g., autism) based on neuroimaging. Welcome uscjobs.sc.edu/postings/194578

Ever wish you could hit "undo" on disease? 🩺🔄 nature.com/articles/s4155… Most drug discovery asks: what does this perturbation do to cells? But we can also ask the reverse: which perturbations undo a disease signature and move cells back toward health? That's the idea behind