Qué es el SITRAME? Nuevo síndrome autoinflamatorio descrito en adultos. Atentos a las características: semejan celulitis recurrentes sobre todo en tronco con fiebre #SCAEDV #Dermatologia

¿POR QUÉ LOS CORREDORES "FITNESS" NUNCA MEJORAN? Me refiero a los gym-bros 💪🏻 Los que “salen a hacer cardio”. Los que dicen que “el cardio engorda”. Los que trotan 20’ en cinta para marcar six-pack. Y es que, no es igual entrenar atletismo que hacer cardio. Vamos a ver... 🧵👇🏻

FDA announced approval of Inebilizumab (Uplizna; Amgen), 1st approved Rx for IgG4-related disease (targets CD19+ B cells). IG4-related Dz is estimated to affect 20,000 in the USA. List price is $140,248.50 per dose, After two initial loading doses it is given q 6 mos.

Encantada de haber participado en esta mesa compartida sobre #AR, hablando sobre los retos actuales que nos exigen mirar más allá de la inflamación. Excelentes moderadores y una compañera de lujo, Hye S. ¡Gracias! #SER2025 Soc.Esp.Reumatología

Year in Review #Basic by Dr. Tsokos #LUPUS2025 ✅NCF1H protects from virus but triggers lupus ✅Rab4A alters T cell mitochondria, reversed by rapamycin ✅UNC93B1 & TASL mutations drive early-onset SLE via TLR7/8 ✅Hormones modulate PTPN22: more severe lupus in males

#Basic by Dr. Tsokos #LUPUS2025 ✅IL-2 therapy expands tissue-homing Tregs:gut (CD38+),skin (HLA-DR+), inflammation (double+) ✅SLE patients show reduced vaccine response,esp. with anti-BAFF(↓B/Tfh priming) ✅Type I IFN triggers mitochondrial sensing & IL-1β release in monocytes

Gluconolactone restores immune balance by suppressing Th17 and promoting Tregs. 🔹Improves skin lesions in lupus-prone mice 🔹Reduces acanthosis and CLASI scores in cutaneous lupus patients after 2 weeks 🔹Modulates metabolic pathways (PPP) in Tregs #LUPUS2025

Lupus Nephritis & Fibrosis Hypoxia in tubular epithelial cells induces ADAM9 via HIF-1α ➡️activates TGF-β1 ➡️drives fibrosis in lupus nephritis 💡Targeting hypoxia-induced ADAM9 could limit renal damage and chronic progression in LN #LUPUS2025

Neuroinflammation in #SLE Anti-NMDAR autoantibodies trigger hippocampal neuronal damage. Sustained inflammation is driven by the HMGB1–RAGE axis and reversed by LAIR-1 upregulation. ACE/AT1R inhibitors also prevent synaptic loss. #LUPUS2025

Obinutuzumab➡️A type II anti-CD20 showed higher renal response rates in LN patients vs placebo in both NOBILITY (Ph II) and REGENCY (Ph III) trials, especially in serologically active patients and those with ⬆️proteinuria. Safety profile✅ Primary endpoints met✅ #LUPUS2025

SLE patients face a ⬆️ 2–3x higher 10-year atherosclerosis risk. Persistent remission & CVRF control slow plaque progression. SGLT2i reduce CV, renal & sepsis events in SLE+T2D. #LUPUS2025

Urinary proteomics in LN identifies 12-protein panels mirroring histological activity & predicting 1-year response. In silico analysis suggests IFN-stratified drug choices (mTORi, anti-CD19/CD38, BTKi) #LUPUS2025

Repeat kidney biopsy in lupus nephritis? 🔹It distinguishes active inflammation from chronic damage. 🔹Only 44% of clinical remissions = histologic remission. 🔹Biopsy helps guide treatment decisions, including tapering. 🔹Biopsy-guided care = fewer flares. #LUPUS2025

Imaging (US & MRI) uncovers hidden inflammation in lupus arthritis. Subclinical synovitis is common, even in the absence of clinical arthritis. Both modalities detect structural changes that may reshape treatment decisions. #LUPUS2025

Subclinical synovitis in #SLE is not benign, it predicts joint progression and damage. Despite unclear treatment guidelines, early detection via imaging may shift management strategies. #LUPUS2025

Valencia, Spain 🇪🇸

¿Recordáis estas fotos de Alcaraz? Cuando perdió ante Goffin, en Miami, Carlitos se fue con su familia y amigos de vacaciones por México. Le llovieron palos por redes, sobre todo de aquellos que le decían que debía ponerse a entrenar. ¿Sabéis qué pasó? Ganó 22 de los

Madre mía que buen artículo sobre la inhibición de pensamientos intrusivos a través de detener la recuperación de recuerdos... os explico cómo! El hilo que todo neuropsicólogx (y psicólogo clínico) necesitaba sin saberlo!