Finally, meet WarpDemuX! Our (Wiep van der Toorn) solution for dRNA multiplexing - so fast it runs on any laptop, and so accurate that we could demux even super low abundance samples with high specificity! And imho the coolest thing? We've also run dRNA live barcode balancing with it 👀

ASO technology using exogenous delivery of antisense oligonucleotides offers many diverse applications, from killing pathogens to reprogramming genetically intractable microbes. Time to organize the first conference on ASOs & microbes! Register at helmholtz-hiri.de

The big consultants haven't just benefited from a weakened state - they've championed an ideology of short-termism and risk aversion in the public sector. Ending this 'consultancy cult' is crucial for transforming our economy. Full article by me and Rosie Collington for

High-throughput transposon mutagenesis in the family Enterobacteriaceae reveals core essential genes and rapid turnover of essentiality mBio from Lars Barquist journals.asm.org/doi/10.1128/mb…

We determined gene essentiality in 13 Enterobacteriaceae including E. coli, Salmonella and Klebsiella strains, and find ~1/3 of the essential genome is variable -- but! there's no evidence for genus-specific essential genes, implying rapid turnover journals.asm.org/doi/10.1128/mb…

🚨 New paper alert! 🚨 Check out the latest publication from Lars Barquist's lab in mBio! Huge congratulations to all authors on this exciting work. Learn more in the thread below! 🧵⬇️

Shall we start calling them „asobiotics“? Probably easier than „antisense-based antibiotics“ or „antibacterial peptide-delivered antisense drugs“, to name just a few of the current names. To be discussed. Anyway, ASOBIOTICS 2024 was a big success. Big thanks to everyone involved.

Happy #InternationalMicroorganismDay to everyone celebrating across the world! 🌐 It's only with such a devoted community that this day has become such a special celebration.😁 Cheers to the #microbes! 🦠 internationalmicroorganismday.org

This is big! Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 Fresh out in The Lancet including age- and geo-resolved data and predictions. thelancet.com/journals/lance…

How do you distill #microbiome complexity into ecologically meaningful units? Clear away the confusion with MICROBIOME FOR DUMMIES: journals.asm.org/doi/10.1128/ia…

I am excited to finally share this preprint from Jörg Vogel. We've developed a reporter assay to enable high throughput discovery of carriers for ASOs into bacteria. This was a challenging and exciting journey for me, from MedChem/ChemBio into Mol/SynBio.

We used in-vitro laboratory evolution to "stress test" the next generation class of antibiotics based on antisense oligos ("asobiotics"). Head over to our new preprint to find out more! (links in the next tweets)

Emergency bulletin! 14 journals have co-published an urgent call for the deployment of microbial solutions against climate catastrophe, by Raquel Peixoto et al. nature.com/articles/s4156…

Interested in multiplexing samples for nanopore dRNA sequencing with the new chemistry? Check out our newly released RNA4 model! 4 barcode model available here: github.com/KleistLab/Warp…

Wir stellen unsere Aktivitäten auf X ein. 👋 Updates zu unserer Forschung und der Welt der Infektionsforschung findet ihr weiterhin hier: LinkedIn: linkedin.com/company/helmho… Bluesky: bsky.app/profile/helmho… Mastodon: helmholtz.social/@Helmholtz_HZI Instagram: instagram.com/helmholtz_hzi/

Der #Wahlomat ist da. Die Bundestagswahl steht vor der Tür und gerade mit den Ereignissen der letzten Woche hat mich die Übereinstimmungen der Parteien interessiert. Daher habe ich das mal ausgewertet.

Now, more than ever, we must embrace #diversity, #equity, and #inclusion in education. A #FEMSMicrobiolLett article explores approaches that empower learners, foster belonging, and spark lifelong learning. #InclusiveEducation #DEI academic.oup.com/femsle/article…

Die Rede von Kevin Kühnert müssen alle Menschen hören. Eine Rede mit historischer Bedeutung.

Turning E. coli into a comic-book hero or villain🦸‍♀️🦹‍♂️🦠 Gozzi et al. show how the Adopt-a-Bacterium method lets biomed students craft memes, games & comics to teach microbiology—boosting engagement, teamwork and #SciComm. #FEMSMicrobiolLett buff.ly/Iw6TncN

How do airway cells react to microbes 🫁🦠🧬? van Woudenbergh et al. show how nasal, nasopharyngeal & bronchial epithelia mount distinct immune responses to viruses and bacteria—helping explain disease outcomes #PathogDis Read the full paper here👉 buff.ly/1czVtK8