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In J. Am. Chem. Soc., we report a platform for red-light photoproximity labeling as we move toward in vivo applications. Congrats to Benito F Buksh, Steve Knutson, James Oakley, @CiaranSeath, collaborators from the Scholes Lab and Alexander Ploss, & the whole team! pubs.acs.org/doi/10.1021/ja…

Just out in PNAS! We report the application of µMap to identify protein targets of small molecule drugs. Both intra- and extracellular targets are demonstrated herein. Great work to the entire team! pnas.org/doi/epdf/10.10…

Using our µMap proximity labeling platform, we report the discovery of novel SARS-CoV-2 entry receptors on the surface of human cells. Congrats Jacob Geri, Steve Knutson, and Alexander Ploss! pubs.acs.org/doi/10.1021/ja…

Taking a BiTE out of KRAS G12C drug resistant tumors with cell surface drug presentation. 🙏 Craik Lab at UCSF for collaborating on our first adventure in biologics. Ziyang Zhang Peter Rohweder UCSF Helen Diller Family Comprehensive Cancer Ctr HHMI cell.com/cancer-cell/fu…

Just out on ChemRxiv! We report a strategy to rapidly access diverse 2-substituted bicyclo[1.1.1]pentanes via new HAT and metallaphotoredox methods. Congrats to the Princeton and Merck Boston team! chemrxiv.org/engage/chemrxi…

Engineering bacteria as interactive cancer therapies | Science science.org/doi/10.1126/sc…

Check out our latest work on the late-stage C–H methylation of drug molecules in JACS! Congrats Edna! pubs.acs.org/doi/10.1021/ja…

Out now in Nature! nature.com/articles/s4158…

In nature, our µMap platform synergizes with the The Muir Lab's split intein tech, where the power of photo-proximity labeling helps us tracks transient, disease-relevant chromatin interactions. Congrats to @CiaranSeath, Antony, and the whole team! nature.com/articles/s4158…

I was taken by surprise this morning when congratulatory emails started arriving in my inbox. I'm incredibly honored, grateful, and humbled to be included among such an esteemed group of scientists, many of whom I’ve admired for decades. While this recognition is individual,

Doubleheader in JACS! An awesome collaboration with Merck on leveraging μMap toward the mapping of protein binding sites. Congrats Sean Huth Sean Huth, James, @CiaranSeath, Jacob Geri, Aaron, and the whole team at Merck! pubs.acs.org/doi/abs/10.102…

Excited to share our latest work on small molecule binding site ID. We demonstrate this application across 7 different protein-ligand pairs and in live cells. Really fun team effort with Sean Huth @CiaranSeath Merck and the rest of the team pubs.acs.org/doi/10.1021/ja…

Interested in converting an aliphatic alcohol directly into its bioisostere? Check out our method for deoxydifluoromethylation of alcohols. Congrats to Edna, Nico Cesar Nicolas, and Holt Sakai! Read the full paper out now in J. Am. Chem. Soc.. pubs.acs.org/doi/10.1021/ja…

Now out from the MacMillan Group in Nature Chemical Biology: “µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.” Congratulations Roderick, Steve, Sean, and Dave on this fine work. Paper here: bit.ly/3z1Vr2O

Check out our latest article in Nature Chemical Biology where an intracellular micromap proximity labeling platform is established to investigate stress granule disassembly mechanisms. Congrats to Roderick, Steve and Sean! nature.com/articles/s4158…

Our latest chemical biology paper is out now in JACS! We developed a platform to profile the phagocytic surface proteome in a temporally resolved manner. Congrats to Sean, Jacob and James! Sean Huth Jacob Geri James Oakley

🎄A new festive µMap photocatalyst and an RNA-seq workflow for profiling the proteomic & transcriptomic magic of nuclear condensates. 🎁🎁🧬🔬Big congrats to Roderick, Niels, Brandon, Philip, Iakovos and MacMillan Group for this Christmas miracle! ✨✨✨ pubs.acs.org/doi/10.1021/ja…

Check out our latest work in JACS, where we sort nitrogen-centered radicals and alkyl radicals across alkenes in a regioselective aminoalkylation reaction. Congrats to Will, Johnny, and our collaborator Jesús from Janssen Spain! pubs.acs.org/doi/10.1021/ja…

The @Stache_Lab has discovered that a black pigment present in many plastics drives depolymerization. Their latest two papers, in ACS Publications and J. Am. Chem. Soc., showcase the potential. Congrats Hanning, Sewon, Liat, Erik, Erin! Enjoy our feature: bit.ly/3PVs4nM