In a case study, a 69-year-old individual with stiff-person syndrome experienced reduced stiffness and increased walking distance after the administration of chimeric antigen receptor T-cells targeting B-lymphocyte antigen CD19. In PNAS: ow.ly/XCmW50SmnPy

Original paper: elifesciences.org/articles/92189…

#FluorescenceFriday #cellbiology #bioart A neutrophilic HL-60 cell exhibits both sheet- and rosette-like dynamic pseudopods as it migrates in 3D through a collagen mesh. Here, the cell center is marked in yellow, and each pseudopod is marked with an orange ball of size

One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is.. youtu.be/db1afWzokOU?si…

Nature research paper: Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain go.nature.com/4fjB4ya

nature.com/articles/s4158… Great work by Elizabeth Kim (Elizabeth Kim) and Xiaoan Wu! Collaboration with teams of Peter Larsson (Linkoping University), Alessio Accardi (accardilab) and Peter Goldstein Weill Cornell Medicine Weill Cornell Medicine Anesthesiology. Free link: rdcu.be/dPAy1

🎉Our 4th research paper on the menthol and cold receptor TRPM8 is now published in Science Advances👉Mechanisms of TRPM8 Desensitization and Inhibition: science.org/doi/10.1126/sc… After a challenging journey, we finally made it. I'm beyond thrilled and proud! #TRPM8 Duke Department of Biochemistry

The electronic version of the translation into Chinese of my book Linear Algebra Done Right is now legally available without cost at linear.axler.net. #linearalgebra

Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday nature.com/articles/nmeth…

Agree 100%

"commonly used Ca2+-indicator AAV transduction procedures can produce artefactual Ca2+ responses"

So many unanswered questions raised by this observation

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Published in Science Magazine: "Direct optical measurement of intramolecular distances with angstrom precision" (Sahl et al.) science.org/doi/10.1126/sc… MPI for Multidisciplinary Sciences Max Planck Institute for Medical Research #Optics #Imaging #Microscopy #MINFLUX #Fluorescence

Join our team to explore Ca2+ signaling and unravel molecular mechanisms underlying health/disease. If you are passionate about advancing scientific discovery, apply now! #ResearchOpportunity #ScienceJobs #Postdoc #CalciumSignaling #Biochemistry jobs.uc.edu/job/Cincinnati…

Corning now offers sterile tips that come in a paper container, thus generating less plastic waste!

Now plasmids for mYongHong (aka mScarlet-3H), an extremely stable RFP from Zhifei Fu lab, are available from WeKwikGene absolutely for free (wekwikgene.wllsb.edu.cn/plasmids?searc…). mYongHong is particularly useful for long-term super-resolution live cell imaging in combination with mBaoJin

Dr. Larry B. Cohen's last paper is now available on bioRxiv! Thanks to Sheng Sheng Zhong for bringing this work online. Miss you, Larry💐 mbl.edu/news/obituarie… Synaptic and Somatic Targeting of ArcLight, a Genetically Encoded Voltage Indicator biorxiv.org/content/10.110…

Thrilled to present the structure of mTORC1 on membrane. We are at an exciting time of using SPA to resolve high-resolution structures of complexes that land on the surface of membranes! Looking forward to seeing what can be done for this research frontier in the near future!

Molecular architecture of synaptic vesicles | PNAS pnas.org/doi/10.1073/pn…