Have been unable to receive emails since Weds. Been on chat since 8:30am this morning. No luck. Microsoft contact us support not working either. No response to tweet Microsoft 365 either.

Update on Microsoft 365. No response from my tweet to them and no resolution of my email issue. :-(

#Mycobacterium infection → neutrophils → #M2 macrophages (anti-inflammatory) within #granuloma core. bit.ly/437q7d4 [open access] [Previous studies: Chronic #inflammatory macrophages → M1-M2 →#homeostasis.]

Brain → #adipokines, #inflammatory cytokines→ activation or dysregulation nerve networks→ #tumor development and #metastasis. Review go.nature.com/446CIOd

“The detrimental role that chronic #inflammation plays in the pathogenesis of #Alzheimer's disease is increasingly recognized”. Excuse me, what is taking people in the field so long? bit.ly/3HtbJCW bit.ly/3d84y29

#Exercise: In vitro: media from contracting primary muscle cells vs non-→ 4.4- and 1.4-fold ↑ in number of #astrocytes and neurons. bit.ly/3AMx4U1

#Menopause reshapes the brain. Hypothalamus neurons → ~ 2x size post-menopause. Transition →#inflammation→ #brainfog →↑ #Alzheimer’s disease and #Parkinson’s? go.nature.com/42lGLEB

Gut #microbiome fluctuates @ different times of the day and between seasons. 57% of bacterial phyla showed 24-hour #cyclicity. #Actinobacteriota ↓ in the morning and ↑↑ toward end of the day. #Diet, fasting periods, sleep, may affect profile. bit.ly/3HTc0PE

In older adults, higher levels of #CRP associated with deficient vitamin D. #VitaminD Tx able to reduce inflammation, a major driver of poor #aging? bit.ly/3PI3847

#VitaminD: ↓ #Cardiovascular issues vs ↑ #cancer risk? #MI + coronary revascularization→ 9%↓. Heart attack 19% ↓. Confidence interval consistent with a null finding. bit.ly/45kXbiA Numerically higher hazard of cancer mortality vs. placebo. bit.ly/47LosMM

In vivo, woodsmoke exposure → issues balancing pro-#inflammatory and anti-inflammatory fluctuations→ #neuroinflammatory and neurometabolomic alterations. Activated #microglial ↑ vs controls even at day28. bit.ly/3Pk8FNR bit.ly/3R8xs8y [open access].

#RBCs → regulate #cytokines and #inflammation. bit.ly/44tzqDz #Intermittant fasting → ↑ immune function of RBCs. bit.ly/3L45WWi [open access].

Hypervirulent #Klebsiella pneumoniae, or hvKp → severe infections in #community settings. Strains with both #multidrug resistance and hypervirulence → #MDR hvKp, also exist. Neutrophils more likely to kill some strains than others. bit.ly/3PrLEbw

Consuming fewer #calories ↑ genes associated with energy generation and #metabolism, and ↓ inflammatory genes, → ↓ #inflammation. bit.ly/46IBFF6 [open access]

“Age-related changes in the expression of ~ 4,000 genes regulating ...#mitochondrial function, protein balance, immune, and #inflammatory responses were related to physical inactivity and inflammation rather than primary #aging.” bit.ly/48pSSmA [open access].

Short-term #heat exposure → #inflammation→ impair adaptive immune response. High temperatures may ↑ susceptibility to infectious agents, environmental exposures, and progression of #cardiovascular disease. bit.ly/43zcJz4

#Fiber-deprived #gut #microbiota → deterioration colonic mucus →lethal colitis. ↑ natural killer cells + altered Ig-A coating → #inflammation.bit.ly/43EaGd6

#Inflammation destroys neurites →#Alzheimer's and #stroke while #sparing neurons. bit.ly/3w0JIzQ

#Inflammation of the intestines → ↑ in #Alzheimer’s disease biomarkers? Continue to study link “between changes in the gut, such as inflammation or increased gut permeability, and Alzheimer’s disease onset and progression.” bit.ly/3YPUEfo go.nature.com/40vMtGv

#Polyphenols→ #inflammation, oxidative stress, #mitochondrial function, and signaling pathways, hold promise for addressing #sarcopenia. bit.ly/40FrocC