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How are #nucleosomes assembled? How can intrinsically disordered proteins chaperone histones? What happens at DNA double-strand break sites? We just added another important piece of the puzzle. Finally out Science Advances: science.org/doi/10.1126/sc…. 1/n

Mark your calander for our FREE Webinar! Protein PTMs in Health and Disease. Organized by tiziana bonaldi and Kris Gevaert Registration and program details - research.ieo.it/our-events/7th… Direct registration - bit.ly/EPICXSregistra…

I am happy to present today at IMSC2022 the recently published work done by the NEMS-MS team Anal Bioanal Chem. The section is Beyond MS. So I am hoping to have some fun questions as a follow up!

DEMON Network Genetics and Omics meeting on Thursday 8th September at 2pm (UK time). Delighted to have Sarah Marzi as a guest speaker - “Cellular deconvolution of histone acetylation yield novel insights into cell-type specific epigenetic regulation in neurodegenerative disease”.

"Alain Aspect, our new Nobel Prize winner in physics, says that he has had time to conduct this research. In France, researchers lack time. They are devoured by bureaucratic activity. Let's trust them, let them work, otherwise they will leave."

A great pleasure to be a part of this mosaic!

I'm a candidate for US HUPO Member-At-Large -- I'm particularly passionate about initiatives to support trainees, both in academia and in industry, so if you'd like to see more of that, please vote for me! Voting is open to US HUPO members now: ushupo.org/Sys/Poll/39354

Never miss this chance!

#recommended #rstats

In 2015, an article in @nature estimated that 800,000,000 USD is wasted annually on nonspecific antibodies. It also suggested standardization, which has not happened. I wonder how much we will spend in 2023 on low specificity antibodies.

Garbage in, garbage out 🚮 Unpopular take in this post-ChatGPT era but the fanciest AI/ML model is still only as good as the data it's trained on 💁‍♀️

Everyone who is happily reporting crazy ID numbers on Astrals, please read the @mjmaccoss paper carefully. It is very good. The 10% false (or at least non-quantitative) precursor IDs translates to even higher false protein level FDR. Let’s not go back to the proteomics circa 2001

Alexey Nesvizhskii @mjmaccoss Reminds me of this blog post proteomicsnews.blogspot.com/2023/06/potent… Could be a lot of PTM diagnostic ions. Or a lot of chemical noise that looks like them…

Another piece of the histone lactylation puzzle falls into place: Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis nature.com/articles/s4158… #lactate #chembio

News in Proteomics Research blog post | TIMSTOF resolving both positional and structural histone markers! proteomicsnews.blogspot.com/2024/08/timsto… --- #proteomics #prot-other

New paper from the group describing UniChromCD for time-resolved CD-MS data, especially with fancy demultiplexing strategies! Great work James "Skippy" Sanders and team! pubs.acs.org/doi/full/10.10… As always, the software is open-source and free

No result can be exciting without strong controls. Quality controls matter at very step, from sample collection to data interpretation.

Our #FragPipe-Analyst manuscript is out! pubs.acs.org/doi/10.1021/ac…. Load FragPipe's TMT/ LFQ/DIA quant tables (peptide or protein quant) and get QC, Limma, PCA, volcano plots, heatmaps, do GO/pathway enrichment analysis, all with just a few clicks! Tutorials:fragpipe-analyst-doc.nesvilab.org

Check out our new protocol avaliable in Methods in Molecular Biology! We describe a straightforward mass-spec protocol for the analysis of histone PTMs and variants Laboratoire de Physiologie Cellulaire & Végétale Exploring the Dynamics of Proteomes (EDyP) Hassan Hijazi Cristel Carles link.springer.com/protocol/10.10…

Incredibly happy to share the recent study in which I contributed where we characterized cell-specific epigenetic erosion of developmental genes in HD mouse striatum. Congrats to Baptiste Brulé, Karine Merienne and all the team for this amazing work! 🖥️🔻 nature.com/articles/s4146…