Out today on the cover of Cell! We created the first high-dimensional spatial atlas of breast cancer progression to understand why some patients with DCIS go on to develop invasive breast cancer while others do not. Michael Angelo @NCIHTAN tinyurl.com/exwnard8

Excited to share our new review about all things MIBI, out in Annual Reviews! As multiplexed imaging technology has advanced, there has been a demand for new analysis tools. We discuss these tools and show examples in various contexts. Michael Angelo 🧵annualreviews.org/doi/full/10.11…

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Excited to announce our first ever MIBI workshop! We'll be talking about the new tools our lab has developed for generating, processing, and analyzing MIBI data. We'll also be going over our workflow for reagent validation, panel design, and troubleshooting pesky antibodies.

Excited to share the latest preprint with Michael Angelo! While imaging studies often focus on cell objects, images capture significant info outside of cells. Enter Pixie, a pipeline for the quantitative annotation of both pixel and cell level features🧵biorxiv.org/content/10.110…

Watch Starship’s first integrated flight test → spacex.com/launches x.com/i/broadcasts/1…

Save the Date! Please join us in August for our 2nd Annual Spatial Biology Workshop! Human BioMolecular Atlas Program (HuBMAP) @ncihtan #spatialbiology Wellcome Leap

Thrilled to share the preprint from my postdoc work in the Bendall Lab with Michael Angelo and Thomas Montine at Stanford Medicine looking at human microglia in situ in #aging and #Alzheimers disease by multiplexed proteomic imaging! shorturl.at/agCN0

Our new Human BioMolecular Atlas Program (HuBMAP) study examining how the maternal fetal interface is established in human pregnancy is out! Big effort led by Inna Averbukh, Erin Soon , Shirley_Greenbaum. So proud of the beautiful study they completed! nature.com/articles/s4158…

I am thrilled to share my preprint with Bendall Lab that includes a new and comprehensive phenotypic atlas of human hematopoietic progenitor cells. Check out how we reconcile the diversity of human HSPCs in the tweetorial below. biorxiv.org/content/10.110…

Super excited to introduce QUICHE (Quantitative InterCellular Niche Enrichment) - a statistical method that can be used to discover local cellular niches differentially enriched in spatial regions, longitudinal samples, or clinical patient groups :) (1/10) biorxiv.org/content/10.110…

I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) biorxiv.org/content/10.110…