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My work with Qing Yu on our new TMT-ABPP at Gygi Lab is now available online. The new method incorporating streamlined sample prep, TMT multiplexing and FAIMS-hrMS2 allows you to analyze ~18k cysteines across 18 samples starting from 10 ug proteome! sciencedirect.com/science/articl…

Congratulations to lab alumnus Devin Schweppe on this well-deserved award!

Our multifaceted tool PISA-REX profiles the proteome of any given biosystem at the dimensions of protein solubility, expression and redox state, at high depth and throughput, for target deconvolution. Grateful to people at the RZLab and the Gygi Lab. onlinelibrary.wiley.com/doi/10.1002/ad…

Check out this blog post and paper from Alberto Cruz-Martín, Rhushikesh Phadke, and colleagues describing how HMSBioPlex helped them link the complement pathway to synaptic dysregulation! communities.springernature.com/posts/beyond-p… rdcu.be/dSTkf

Congratulations to Steven Shuken on this impressive achievement!

Happy birthday to Proteomics!

Collaborative efforts with Gygi Lab, Hans Widlund, Kai Wucherpfennig Labs Dana-Farber Cancer Biology Department Dana-Farber #HarvardCellBiology Brigham and Women’s Dermatology Harvard Medical School Be on the lookout for a 🧵by Tevis Vitale for a more detailed explanation!

I’m so grateful to have worked with these wonderful people on this awesome paper that came out in Cell today! Linking ALK phosphotyrosine signaling through GUK1 to regulate GDP/GTP levels in cancer. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2… @HaigisLab Gygi Lab Cell

It's great to see lab alumnus Jose Navarrete-Perea featured in JASMS. While in the lab, Jose played a key role in our TMT and instrumentation work and was an essential part of our HMSBioPlex project, and much more. Congratulations, Jose! Am Soc for Mass Spec pubs.acs.org/doi/10.1021/ja…

Check out MuSIC 2.0, combining Human Protein Atlas images and HMSBioPlex interactions to make a multi-scale model of the cell. I enjoyed working on this with Trey Ideker, Emma Lundberg + their labs & collaborators. Special congrats to lead authors Leah Schaffer & Clara (Mengzhou) Hu!

Check out this paper to read how HMSBioPlex interactions can be combined with Human Protein Atlas images to model the cell! Leah Schaffer, Clara (Mengzhou) Hu Trey Ideker Emma Lundberg Ed Huttlin

Congratulations to all this year's Am Soc for Mass Spec award winners, including Gygi lab alumnus Qing Yu!

It’s also worth mentioning that the AP-MS data in this study was collected by the HMSBioPlex team at Harvard Medical School.

I was quoted in this very well done story by Mary Kekatos at ABC News highlighting some of the grants that were tragically and needlessly terminated including mine. abcnews.go.com/US/350-harvard…

#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how HMSBioPlex is enhancing drug discovery! Harvard Medical School Am Soc for Mass Spec

If you're going to #ASMS2025, don't miss these presentations from members of the Gygi lab! You'll learn about TMT, chemoproteomics, GoDig for targeted proteomics, leveraging HMSBioPlex for drug discovery, new instrumentation, and much more! @edhuttlin Steven Shuken Amanda Smythers, PhD