#pathCast #ENTPATH #NOSEALARM by Dr. James Lewis from Mayo Clinic Pathology

Let's learn hematology in 2025🩸 Day 5: structure of the bone marrow

Serotonin-producing pancreatic neuroendocrine tumors have a peculiar sclerotic background that is a clue to the diagnosis. Depoilly T, Leroux R, Andrade D, Nicolle R, Dioguardi Burgio M, Marinoni I, Dokmak S, Ruszniewski P, Hentic O, Paradis V, De Mestier L, Perren A, Couvelard

This pancreatic ductal adenocarcinoma spread to the ovary despite negative frozen section margins! Well, duh, the two are unrelated. Folks, we are wasting time on those stressful frozens for essentially no benefit to patients - read all about it! Li X, Malik P, Bhalla A,

Evaluating HER2-low breast cancer (OPEN ACCESS) 🧬 It's low—even among experts. Subspecialised breast pathologists showed poor agreement in assessing HER2-low breast cancer. 🧪 A modified algorithm (based on Ki-67 scoring) was tested to improve consistency, but showed only a

🔬 Papillary Fibroelastoma ~ ✴️ "Sea Urchin" #Pathology #Heart #Cardiovacular #CVpath

Soft tissue tumors with fascicular morphology- three differential diagnoses to consider -Synovial sarcoma (pic👇) -MPNST -Fibrosarcomatous DFSP Dr. Fritchie- Comprehensive and Immersive Soft Tissue Pathology Course-May 2025 #pathology #BSTPath #PathX

Pitfall alert! Dedifferentiated liposarcoma can aberrantly stain with CD117, which may be problematic in biopsy from an intra-abdominal mass. Resection showed clearcut abrupt transition between well-differentiated and dedifferentiated liposarcoma. #TheJPCNCR #PathTwitter

#USCAP2025 w/ Dr Voltaggio Esophageal ⬆️ grade dysplasia/intramucosal adeno → treated with EMR. Presence of muscularis mucosa = lateral margin; large vessels + loose CT = deep margin. Recommendation to pin specimen before fixing for easier margin assessment. #PathWebinarPearls

#USCAP2025 w/ Jason L. Hornick, M.D., Ph.D. Undifferentiated and dedifferentiated melanomas are tough 😨, they have lost staining for conventional melanoma markers. Using mutation-specific IHC BRAF V600E and considering clinical history (ie. axilla) are key for diagnosis. #PathWebinarPearls

Important message No2! #IACwebinar with Dr Mauro Saieg, MD, PhD, FIAC Pancreaticobilary #classification #cytology International Academy Cytology Esther Diana Rossi Ivana Kholová Lola Lozano

S100 positive mesenchymal neoplasms Dr. Fritchie- Comprehensive and Immersive Soft Tissue Pathology Course-May 2025 #pathology #BSTPath #PathX

Modern immunohistochemistry can be so reassuring on tiny needle biopsies, like the ones for this chondromyxoid fibroma. 1PMIDs: 10349990. PMID: 35650682; PMCID: PMC9481662.

1st European Joint Meeting of the International Society of Dermatopathology #ISDP #dermatopathology Dr. Kempf on CD8 lymphoproliferative disorders

🧬 CML updates 2025 📌 WHO: 🚫 Accelerated phase → now CP low-risk vs high-risk (with BP features) 📌 NCCN: Frontline TKIs → 1G (Imatinib), 2G (Bosutinib, Dasatinib, Nilotinib) ✅ ✨ Ascinimib (allosteric TKI) added as Cat.1 option #CML #SOHO25

Normal synoviocytes -They stain positive with D2-40 and also they can have desmin positivity -CSF1 (CISH or IHC) is positive Dr. Nielsen-Neoplastic and Non-Neoplastic Lesions of the Synovium #USCAP25 #PathX #BSTpath

Usual Ductal Hyperplasia-helpful HE clues - Nuclei is variable and touch the lumina (pic 1) - Pink intranuclear pseudoinclusions (pic 2) - Nuclear grooves (pic 3) Dr. Cimino-Mattews-Contemporary issues in Breast Pathology #USCAP #PathX #pathology

🧠Meningioma histology at a glance — condensed from the WHO CNS Tumor Classification. Educational summary for residents and trainees: histology, molecular features, key IHC, and radiology examples. Source: WHO CNS Classification #Pathology #Neuropathology #Meningioma #UTMB

Inguinal LN CNB 70 yo male. Low and high power, CD21, PD-1. What is the typical mutation for this lymphoma?

My weekly lymphoproliferative disorders: many tru-cut lymph node biopsies. I hope that they are representative samples. #path #hematology #pathology