Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new Arc Institute work, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

Feng Zhang... Fyodor Urnov... Alexis Komor... Nicole Gaudelli... Neville Sanjana... Julia Makani... Beth Shapiro... + Sessions from Revvity Taconic Biosciences 'The State of #CRISPR and Genome Editing' June 11 FREE! webinars.liebertpub.com/e/the-state-of…

We've been working on this resource for months: A VISUAL GUIDE TO GENOME EDITORS. Learn how tools like Cas9, Cas13, prime editors, and Bridge editors work - with diagrams! We hope this becomes a valuable resource for the biology community and students.

Join Nucleate UK's two-day hackathon in London (June 28–29, 2025) to explore how AI and synthetic biology can unlock underutilized crops and reshape UK agriculture—addressing climate change, pests, disease, and reliance on staple crops by decoding genetic traits for resilience,

Check out our new preprint! We examined sources of variability of transgene expression in N. benthamiana agroinfiltration and ways to minimize it. Graduate student Sophia Tang observed FP expression in >1,800 plants over the course of nearly 3 years! biorxiv.org/content/10.110…

New Perspective: "Virus-induced gene editing free from tissue culture" rdcu.be/etNik Recent work has brought virus-induced editing closer to achieving its promise to simplify plant gene editing by weaning it from its dependence on tissue-culture-based transformation.

Here's a fun plasmid from many many years ago I just resurrected. This is p100bp, a ladder-making vector that produces a DNA ladder when cut with EcoRI. I got this from the legendary Open Biotechnology company that sadly went under. Looking forward to adding to my shop.

"in vivo MutaT7 mutagenesis-mediated screening pipeline to evolve oxygen-tolerant rubisco in E. coli" In vivo directed evolution of an ultrafast Rubisco from a semianaerobic environment imparts oxygen resistance pnas.org/doi/10.1073/pn…

1/4 🚀 Announcing the 2025 Protein Engineering Tournament. This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️ #AIforBiology #ClimateTech #ProteinEngineering

A new #CRISPR Cures center, funded by $20M from Chan Zuckerberg Initiative and led by Fyodor Urnov, will create 8 custom therapies for patients in the next 3 years. “Our goal is to aggressively walk the walk of CRISPR platformization,” Urnov told me. More in Endpoints News: endpoints.news/crispr-cures-c…

🇫🇷 French wheat might be local. 🇨🇦 But Canadian wheat is cleaner. Yes, even after crossing the Atlantic. Here’s why 🇨🇦 outperforms 🇫🇷 on carbon footprints, and what it means for sustainable farming. 🧵1/

Same crop. Same planet. Completely different climate impact. Let’s break down why: 👇3/

Big drop Monday: my first two official artworks go on sale as part of my 1000 flower collection🌹✨ The launch comes with an Asimov Press article by the legend Niko McCarty., diving into the art and science behind the flower genetic design project!

A flower designer in the UK ( Nick Desnoyer ) is using breeding, genetic engineering, and even pathogenic infections to create 1,000 original flowers. His name is Nick Desnoyer, and he does this work in his spare time, after his labmates have left for the day. He does not make

Introducing the 1,000 Flower Collection 🧬🌹 I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes. Here’s how I’m making it happen…  and how you can join me on this journey 🧵(1/7)

To promote the collection, I’ve launched a designer clothing line where synthetic biology meets aesthetics. I will give out 100 free limited edition shirts to the first who retweet and order with their handle in the name! Available here → nickdesnoyer.com  🧵(6/7)

Toward a monocot #SynBio toolkit: assessing regulatory element performance and eudicot compatibility link.springer.com/article/10.100…

Nigeria, Kenya, Ghana, and Malawi are now embracing gene editing on their own terms, crafting regulatory frameworks that treat CRISPR and similar tools not as GMOs geneticliteracyproject.org/2025/08/11/afr…

Imagine if every historic square became a forest. 🌳 Should cities worldwide reimagine their iconic plazas this way—balancing history, climate resilience, and livability? 👇

A new paper in Cell shows that it is possible (simple, really) to convert DNA-editing CRISPR proteins, such as Cas9, into RNA editors. All you have to do is delete a chunk of them. Deleting 55 amino acids from a DNA editor called IscB (the ancestor of Cas9) turned it into a