How are genomes neatly packaged for cell divisions? Our awesome collaboration with @HaeringLab @EMBL Universität Würzburg #UniWürzburg reveals intriguing #cryoEM insights into the mechanism of DNA loop extrusion by SMC complexes: embl.org/news/science/s…

New EMBL research by the Eustermann lab reveals how the packaging of DNA into hexasomes impacts the function of remodeling enzymes involved in gene regulation. Read more: science.org/doi/10.1126/sc…

Check out how the INO80 complex interacts with non-canonical nucleosomes. Great team effort by M. Zhang, A. Jungblut and F. Kunert. Congratulations to the EustermannLab EMBL and all authors!!! science.org/doi/10.1126/sc…

How to remodel a hexasome? Check out our new findings on non-canonical nucleosome remodeling Science Magazine. Great EustermannLab team effort @EMBL together with hopfnerlab and Frank DiMaio. science.org/doi/10.1126/sc…

Special thanks goes to Min Zhang Min Zhang, Anna Jungblut EustermannLab and Franzi Kunert @ hopfnerlab science.org/doi/10.1126/sc…

EMBL researchers have provided the first detailed structure of human RNA polymerase III transcription factor IIIC (TFIIIC). The findings offer vital insights on TFIIIC’s cellular functions to those studying its role in chromatin organisation and cancer. science.org/doi/10.1126/sc…

Super excited to present #Blush and with it expand the applicability of cryo-EM. We reconstruct one of the smallest complexes ever with cryo-EM. A 40 kDa protein-RNA complex. biorxiv.org/content/10.110… But how do we make sure we’re not overfitting? 🧵1/4

1/10 With great pride I present our newest #CryoEM work pub. in nature. The 1st reported secondary-active transporter directly activated by membrane voltage. Full credit to the amazing Valeria Kalienkova 🇺🇦🌻, Martin Peter & Jan Rheinberger 🧵👇🏽 for more info nature.com/articles/s4158…

Congrats Sandipan Brahma!!! The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes nature.com/articles/s4158…

The simple autophagy adaptor protein Atg18 has many levels of structural self-organization in particular with lipid membranes! Wonderful collaboration with the Andreas Mayer lab (Lausanne) and with two leading authors @FrommSimon Daniel Mann . doi.org/10.1038/s41467…

BIG NEWS No 2 🥳🥳🥳 ! Together with Paul Langerhans Institute Dresden - PLID Deutsches Zentrum für Diabetesforschung (DZD) Helmholtz Munich | @HelmholtzMunich TU Dresden and @Medizin_TUD As of April 1st Ingmar Schäfer of conti_lab and Max Planck Institute of Biochemistry (MPIB) is appointed as Professor and Chair of Structural Membrane Biology at PLID and ZML.

This is an amazing course with an all-star lineup of instructors 🤩 It will cover the theoretical and practical foundations of advanced cryoEM techniques, from sample preparation to data collection to image processing. You have one month to apply!

Happy to share with the world that the main body of my PhD thesis (and my rotation project) on the mechanism for replisome-mediated parental histone inheritance is published in Cell today🥰! cell.com/cell/fulltext/…

1/ 🤔 Do #chromatinlooping-mediated promoter-#enhancer interactions drive gene expression? Or is the local enrichment of transcription factors into hubs/#condensates the key factor? Our AC/DC model of gene regulation at bioRxiv doi.org/10.1101/2024.0… provides a new view on this.

Our latest paper is out today Molecular Cell! Led by a Alberto Hernandez-Armendariz and with important contributions from Andela Saric & @EllenbergLab! We show how chromosomes shift from being repulsive to becoming attractive during mitosis. Read all about it here: cell.com/molecular-cell…

A huge shoutout to our #EMBOCryoEM participants! 👏 The last 9 days were full of lectures, practicals, and social activities - well done for showing up each day with renewed enthusiasm and making this course memorable ✨ See you again soon? 👉 embl.org/events

New work from the lab! James Stowell led this project showing the importance of multivalency and phospho-regulation in mRNA decay. This has many parallels with other mechanisms in gene expression... 🧵 1/ #RNA #NMR #bioRxiv @MRC_LMB European Research Council (ERC)

Congratulations to Michael Dorrity of EMBL, Heidelberg, Germany on being awarded a FEBS Excellence Award, which provides €100,000 in research funding Michael Dorrity #FEBSExcellenceAwards febs.org/news/febs-exce…