Our very first Structural Genomics Consortium (SGC) Open Chemistry Networks meeting later today (5pm UK). Project 4, SARS-CoV-2 Nsp13 fragment project, chaired by student champ Tom Knight. Details: github.com/StructuralGeno… All welcome. #openscience #SGC-OCN #SGCchem Target 2035 #FBDD

Through its participation in Innovative Health Initiative EUbOPEN, Pfizer Inc. is helping to support the generation of chemical tools which may help scientists develop compounds that target proteins as specifically as possible. #PFEColleague bit.ly/3ua9TQY

The Bullock lab has a new paper in Cell Death Differ “Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation” showing how mutations change E3 ligase substrate recognition. DOI: 10.1038/s41418-022-00983-4

Register now for the next Target 2035 webinar!

This is a great webinar series! FragileNucleosome also have YouTube channel youtube.com/channel/UCAnaB…. cc: EUbOPEN

Groundbreaking work from Cheryl Arrowsmith, Structural Genomics Consortium (SGC) team U of T Research, Princess Margaret Cancer Centre Research and research partners released today in Nature Chemical Biology reveals MS023 induces #antitumor activity for #triplenegativebreastcancer. Read more here: go.nature.com/3wsL5DH

It's here: you can now download all the data on the Chemical Probes Portal! Use our new feature to download the full dataset, choose individual chemical probes or filter by protein target, target family, expert rating etc. Find out more: chemicalprobes.org/news/new-featu…

We're seeking inhibitors of #PLCzeta1 towards new, inexpensive, non-hormonal female contraceptives. You'll work with other target champions across the worldwide Structural Genomics Consortium (SGC) - a very strong, collaborative team funded by the Gates Foundation. #globalhealth 2/3

Interested in a new challenge? Check out this role for a Senior Scientist and Programme Leader at Centre for Medicines Discovery cmd.ox.ac.uk/jobs#157818

cc: EUbOPEN

This Tuesday JUNE 14 10AM EDT/4PM CEST Target2035 Webinar: Towards Autonomous Bioactive Molecular Discovery! Register NOW target2035.net/upcoming-webin…

RT EUbOPEN #trainees #phdstudent #chemicalbiology

Happy to share that they liked my flash talk enough to give me a prize at the #SeedpodsDay! Life pro tip, wear a baby bump as a good luck charm!

Don't miss your opportunity to take part in the second #CACHEChallenge! The target is the NSP13 helicase of #SARSCoV2. Submit your application to join the CACHE competition. Apply today! bit.ly/3bqngFW #DrugDiscovery #OpenScience #Target2035

🙌 EUbOPEN is fully committed to #OpenScience and aims to publish all its generated data open and fully #accessible to everyone. Read our case study 📄 on EUbOPEN to find out our collaboration on making data #FAIR: fairplus-project.eu/news/eubopen-c…

Register now for Target 2035's upcoming webinar on February 21 and learn all you need for XChem, a dedicated platform for crystallographic fragment screening. Daren Fearon Diamond Light Source Lizbe Koekemoer Centre for Medicines Discovery @EubOPEN bit.ly/3jBYlU6

The 2nd EUbOPEN annual meeting was successfully held earlier this week. Among affiliated partners, SGC showcased a strong presence, by sharing updates on our progress toward the consortium's goal of generating chemical modulators for the entire druggable proteome.

In the last #20yearsSGC, we're thrilled to be part of the EUbOPEN consortium, an endeavor dedicated to developing high-quality chemical tool compounds for 1,000 proteins. Over the past 3 years, our collective efforts have yielded remarkable achievements.

EUbOPEN partner @AlessioCiulli, pioneers a molecule that targets a previously "undruggable" protein class! By ingeniously masking the molecule, it can enter cells paving the way for innovative disease treatments. nature.com/articles/s4146… @IMI Centre for Targeted Protein Degradation