Lots of Octant Bio news to share today, including our Series B led by Catalio Capital Management George Petrocheilos. Immensely thankful for the support, including a16z Bristol Myers Squibb Fifty Years Gaingels 8VC Allen & Company LLC and many more amazing investors and angels, too long a list for here

Exciting news today on many fronts! Pumped to be going back to my DMS roots in collaboration with Bristol Myers Squibb

Very happy to announce the close of Octant Bio’s $80M Series B, led by Catalio, along with a16z, 8VC, Bristol Myers Squibb. Looking forward to working with Sri Kosuri, ramsey homsany & their team to further develop Octant's innovative synthetic biology platform fiercebiotech.com/biotech/wild-w…

Where are allosteric hotspots located in a protein? What properties differentiate such hotspots from other residues? We combine deep mutational scanning of four homologs with machine learning to reveal molecular rules governing allosteric hotspots. biorxiv.org/content/10.110…

Excited to be here at #VariantEffect22 with my other Octant Bio colleagues. A great kickoff to the conference hearing about how clinical data + functional data can be used to improve variant interpretation Conor Howard Diane Dickel Sri Kosuri Nathan Abell

🚨PREPRINT ALERT!!!🚨 I’m beyond excited to finally share this work, where we demonstrated the use of temperature-jump as a perturbation for time-resolved crystallography, specifically to study protein dynamics! 🔥💎 biorxiv.org/content/10.110… 🧵 1/32

Ok fellow MAVE/DMS enthusiasts, I think the time has come that we standardize heat map coloring. Personally like blue for gain of function, red for loss of function (reasoning red = bad in my mind) but could be persuaded otherwise Atlas of Variant Effects Alliance #VariantEffect22

.Kresten Lindorff-Larsen on disentangling stability-activity-folding contributions of variants that are important for fxn and using this data to predict effect mechanism for disease variants #VariantEffect22

Have to give a special shout out to my old labmate Willow Coyote-Maestas, presenting on a library generation method, DIMPLE, to address the difficulty in making systematic indel libraries. He recently started as a Hannah Gray Fellow, go check out his work! #VariantEffect22

Happy to share the bioRxiv for my first bit of work w/ Alice Ting. Together with Heegwang Roh, we built a simple and versatile single-component luminescent biosensor for detecting the SARS-CoV-2 spike protein. biorxiv.org/content/10.110…

Have you ever wanted to make a library that includes indels? Well now you can! Super excited this is finally out, congrats Willow Coyote-Maestas

Very cool, especially re: structure based drug design! Congrats Keedy lab, again proving RT is best 🔥🔥