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Study employs CRISPR/Cas9 loss-of-function screens to simultaneously investigate the contribution of the entire transportome in regulating the toxicity of arsenic, cadmium and mercury in human cell lines. CeMM, Superti-Furga Lab, Andrè Ferdigg, and Giulio Superti-Furga hubs.la/Q02ZpNFX0

ciBAR1-KO mice exhibit ciliopathy phenotypes such as embryonic lethality and exocrine and endocrine pancreatic defects, indicating that ciBAR1 plays a critical role in ciliogenesis in vivo. StonyBrook Biology life-science-alliance.org/content/8/2/e2…

In a new paper @TaschnerMichael and co describe a cloning platform supporting quick and efficient optimization of heterologous expression of protein complexes. DMF UNIL @Gruber_Lausanne @TaschnerMichael life-science-alliance.org/content/8/1/e2…

Morphoregulatory ADD3 controls glioblastoma stem cells (GSC) connectivity, proliferation and chemoresistance, showing that GSC morphology is a new layer of tumor heterogeneity. Nereo Kalebic Carlotta Barelli Human Technopole hubs.ly/Q02ZC6r30

mRNAs with intact 5′SS motifs must be m6A-modified to be nuclear-retained by a conserved pathway that includes YTHDC1/YTHDC2, ZFC3H1 (a PAXT complex component), and U1-70K (a component of the U1 snRNP). uoft_biochemistry life-science-alliance.org/content/8/2/e2…

Here authors show that colorectal cancer cells express hemoglobin delta and the alfaD/beta 1 integrin. They form a cell surface complex, which facilitates oxygen uptake and cell adhesion. Inhibition of either molecule prevents cancer cell proliferation University of Helsinki

Enhancing RuvBL1, but particularly RuvBL2 expression, reduces toxic dipeptide repeat proteins in in-vitro and in-vivo models of C9orf72-linked ALS/FTD, suggesting that modulating RuvBL1/2 levels could be a promising therapeutic approach for C9ALS/FTD. @neurosheff

Vascular dysfunction is at the onset of oxaliplatin-induced peripheral neuropathy symptoms. Brunet lab identifies that vasodilators can alleviate neuropathic symptoms, highlighting the importance of vascular health in OIPN treatment. CIRB_CdF Sonia Taïb life-science-alliance.org/content/8/2/e2…

New study by KarolinaBorankova Jan Škoda unexpectedly reveals that depleting the mitochondrial fission mediator DRP1 does not impair pediatric sarcoma chemoresistance and growth, ruling out DRP1 as a therapeutic target in these tumors. Masaryk University International Clinical Research Center

RNA endo-bind-n-seq allows for the identification of RNA elements that are bound by RBPs, which are isolated from their physiological environments using immunoprecipitation and RNA selection. Meister lab Tiana Hanelt Universität Regensburg hubs.la/Q02-5bjg0

ciBAR1 loss in mice causes laterality defects, pancreatic degeneration and altered glucose tolerance. StonyBrook Biology hubs.la/Q02-567b0

Check latest work by Liu et al. on benchmarking structural variant prioritization tools for better genomic research! #SVanalysis Xuanshi Liu life-science-alliance.org/content/8/3/e2…

A mitochondrial signature provides clues to understanding the mechanisms of therapeutic resistance in melanoma and could represent a potential tool for predicting the efficacy of targeted therapies.Faculté de pharmacie Simon-Pierre Gravel life-science-alliance.org/content/8/3/e2…

N-6-methyladenosine (m6A) Promotes the Nuclear Retention of mRNAs with Intact 5′ Splice Site Motifs uoft_biochemistry hubs.la/Q02-j8PQ0

To streamline expression construct preparation for screening in diverse expression hosts the authors present vectors and protocols using Golden Gate ligation to guide one-step Gibson Assembly DMF UNIL @Gruber_Lausanne @TaschnerMichael hubs.la/Q02-55Yw0

Genes important for Notch trafficking and signaling in human epithelial cells uncovered Thomas Vaccari Università degli Studi di Milano life-science-alliance.org/content/8/3/e2…

Hypoxia favors tumor growth in colorectal cancer in an integrin αDβ1/hemoglobin δ-dependent manner University of Helsinki hubs.la/Q02-jgzs0

Huschet et al. establish and benchmark a nuclear proteomics workflow that is faster, simpler and more scalable than classical protocols, while being as efficient, specific and reproducible. Universität München life-science-alliance.org/content/8/3/e2…

This work presents two new computational methods for reconstructing tumor cell lineage trees from single-cell copy number data. UConn life-science-alliance.org/content/8/3/e2…

RuvBL1/2 reduce toxic dipeptide-repeat protein burden in multiple models of C9orf72-ALS/FTD @neurosheff hubs.la/Q02-Hyy_0