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Great article in the The Washington Post by carolyn johnson on the development of structure-based RSV vaccines! It's an exciting time in the field given the recent positive phase III results from GSK and Pfizer Inc.. washingtonpost.com/health/2022/10…

Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student Elizabeth McFadden! biorxiv.org/cgi/content/sh…

I've been playing around with AlphaFold3 since the server was released and, like others have noted, I'm seeing a lot of odd pathological behaviors. For instance, when given 2 copies of this particular protein (+lipids), it more or less just superimposes the structures 1/n

We tracked a pandemic decimating beetle colonies and used cryoEM for sequencing-free discovery of the new virus that caused it. This virus is crazy; parvoviruses aren't supposed to have such structured protein-DNA interactions. We fulfilled all 4 of Koch's postulates for etiology