Please RT: We are recruiting an Assistant Professor to join the microbiology research cluster in my department Biological Sciences UofC and to nominate this recruit for a Tier II Canada Research Chair CIHR in Microbial Genetics for Microbiome Editing 🥼🔬🧬🧫🧪 careers.ucalgary.ca/jobs/14226660-…

Congratulations Alyssa! 🏆 Exactly two years on from the day she began her life-changing clinical trial, Alyssa attended a special ceremony last night, sweeping not just one but two awards! 'Young Person of Courage' and the 'Young Person of the Year 2024'.🌟 Leics Lieutenancy

Also with Alberto Ciccia and Pierre Billon (a little Ciccia lab reunion!)

Thank you Raquel Cuella Martin for organizing a fantastic workshop in Barbados! So great to reunite with you and Pierre Billon!

Excited to share some of my PhD work was pre-printed! Using single-cell sequencing, we took a deep look at a library of CAR signaling architectures to try to identify signal-intrinsic drivers of CAR-T function🧵👇 Michael Birnbaum Koch Institute at MIT MIT Dept of BE biorxiv.org/content/10.110…

Northern lights from our balcony in Calgary. #canada #alberta #calgary #auroraborealis #nothernlights #lights #yyc

Now online! TULIPs decorate the three-dimensional genome of PFA ependymoma dlvr.it/T9ND3b

Please RT: My team is hiring! We are looking for a talented microbiologist with experience in genetics and anaerobic culture. We seek to understand how gut bacteria can affect our brains, behaviour and happiness. Apply at link below. U Calgary Biological Sciences UofC internal.careers.ucalgary.ca/jobs/14669563-…

In vitro, multiple #DNA_repair proteins Ku load from DNA ends on linear DNA, eventually covering it. Yet, in cells, only one Ku is found per DNA end at double-strand breaks. What restricts Ku entry on chromatin? doi.org/10.1016/j.celr…

Check out NuA4/TIP60 in Science Magazine . We show how this molecular Swiss army knife integrates histone exchange and acetylation in one complex to maintain genome stability 🧬 Congrats to zhenlin and @mameri_amel who co-first authored this work! 🧵⬇️ twtr.to/157Oh

So happy this is finally out. Fantastic collaboration with The Nogales Lab to obtain high resolution structure of the human NuA4/TIP60 complex and investigate the function of the TRRAP subunit in recruitment. science.org/doi/10.1126/sc…

Really proud to see this work published -- a thrilling detective story I was lucky to be a part of. Big kudos to Stephen Tang and the entire team for an impressive collaborative effort. See Stephen's thread below to learn more... (and read the paper!). drive.google.com/file/d/1_paZuA…

Hello, I'd like to invite you to do my laundry for me. If you accept, I ask that you do my laundry in the next 7 business days. If you decline, please give a reason, and recommend 2-3 colleagues who can do my laundry instead. No, of course there's no payment, what a crazy idea

We are hiring! The Corcoran lab seeks individuals with molecular virology or RNA biology experience to work on the kaposin RNA and its role as a non-coding architectural RNA that optimizes KSHV infection. Please share!

Columbia welcomes CAR-T pioneer Michel Sadelain, MD, PhD, as the inaugural director of the new Columbia Initiative for Cell Engineering and Therapy and director of the Cancer Cell Therapy Initiative at the Herbert Irving Comprehensive Cancer Center. ➡️columbiamed.link/3zCR9iI

🥳Today pnas, we reported CRISPR-Translate, a genome-wide CRISPR-Cas9 knockout screen-based method designed to identify factors regulating translation. We discovered IRF2 as a novel regulator of OAS3/RNase L-mediated RNA decay during viral infections. pnas.org/doi/10.1073/pn…

We are organizing a FREE small symposium on DNA replication and replication stress on December 2nd and 3rd in Montpellier, France. Slots are still available for posters and talks. More info here: replication.sciencesconf.org

New Lab Preprint! We show that ATR inhibition leads to PARP1 hyperactivation at replication forks, driven by an APOBEC3B-initiated reaction cascade involving UNG2 and APE1, which targets unprotected single-stranded DNA at the forks. biorxiv.org/content/10.110…

Kariko's publishing record is not, IN ANY WAY, a rebuke of our impact-obsessed publishing system. Only in the HHMI Comic Universe are these Kariko papers low impact. In the real world this is a high prestige, difficult to achieve publishing record. And you can see if you read

Life expectancy.