Zones & Patterns of Liver Injury Zone 1 (ALT > AST) ▪️Autoimmune hepatitis ▪️Viral hepatitis Zone 3 (AST > ALT + ⬆️ LDH) ▪️Ischemia ▪️Toxic events ▪️Heart failure ▪️Budd-Chiari syndrome Note: ALP is predominant in basolateral membrane #LiverTwitter 👊

1. Introducing a new thread: super basic lung pathology for PGY1s, with arrows. If you are a PGY1, leave a comment and I will tag you in a future post. A hamartoma is a disorganized mix of overgrown normal tissues (in their normal location) that creates a mass. Good news: they

✅ #LUPUS #NEPHRITIS update - ISN/RPS 2003 findings - Suggested 2018 updates - Typical presentations - (Some) Autoantibodies (#membranous) Would love some feedback 🔄 from the #nephrology colleagues 👍

Epidemiology of Renal Cell Carcinoma 🔬 europeanurology.com/article/S0302-…

🦋Lupus Nephritis Management Infographic by Dr. Ambily K KDIGO guidelines 2024

Immunotactoid glomerulopathy (ITG): 45-yr old with hematuria, proteinuria, Non-Hodgkin lymphoma LM: MPGN pattern IF: IgG kappa Subtype: IgG1 EM: microtubular deposits along capillary wall IgG deposits are usually monoclonal (monoclonal ITG) & associated with a lymphoma. 1/2

𝗧𝗢𝗗𝗔𝗬: ISN Webinar: "Kidney Transplant Pathology, Banff Classification" 🗣️ Wesam Ismail, Diana Taheri 👤 Shokoufeh Savaj, Bassam Saeed 🗓️ November 12 🕚 2 pm CET 🔗 Free registration: ow.ly/5otw50TXvfa

The ISN/RPS 2004 classification of lupus nephritis is entirely based on glomerular changes. Depending on the presence or absence of active and/or chronic glomerular lesions, cases are allocated into one (and occasionally two) of six possible classes. The most commonly encountered

The Nephrology Board Review & Certification Exams Edition (Part 1)- high yield content for exams not only in the US but also worldwide (in addition to being pertinent clinically). Contents below AKDH NKF Nephrology Professionals Charuhas V Thakar Jeffrey William St Vincent's University Hospital (SVUH) sciencedirect.com/journal/advanc…

This is difficult & rare. Suspicion is key. LM-large glomeruli, appear hypercellular, but a closer look & you see foam cells. Stain for CD68 & glomerular capillaries light up & are filled with CD68+ macrophages. IF/EM essentially negative. Dx: Histiocytic glomerulopathy 1/3

Very happy with this publication! Hopefully it will help trainees in #renalpath and #nephrology. Thanks Cynthia Nast, MD! Immunofluorescence Use and Techniques in Glomerular Diseases: A Review karger.com/gdz/article/do… Renal Pathology Society GlomCon WashU Nephrology

Breast-Cystic Neutrophilic Granulomatous Mastitis (CNGM) Histologic criteria 1-Lobulocentric inflammation 2-Cystic spaces rimmed by neutrophils 3-Non-necrotizing granulomas 4-Gram stain with gram positive corynebacteria If you have at least 2 of the first 3 criteria and a

Patient with acute kidney injury following vancomycin treatment for pyelonephritis. Numerous unusual casts (no LC restriction, myo/hemoglobin and chromo negative). EM shows mixture of uromodulin protein and precipitate. C/W vancomycin cast nephropathy. #renalpath #nephrology

According to the ISN/RPS 2003 classification of lupus nephritis, membranous lupus nephritis (class V) is characterized by the presence of global or segmental subepithelial immune deposits with or without associated mesangial deposits or mesangial hypercellularity. Membranous

All "full house" is not lupus and all lupus is not "full house". #lupus #biopsy #IF Anila Abraham Kurien GlomCon

1/6🩺 Clinical Pathology Case @MGHKidneys Mass General Transplant MGH Pathology Today, we reviewed a 50-year-old man with end-stage kidney disease, who received a kidney transplant in 2020. 🕒 Fast forward 4 years: He presented with rejection, and here’s what we learned! 🧵👇

Membranous nephropathy antigen #MN #CKD #antigen Sowrabha Rajanna Subashri Dr. Hardik Patel 🩺💉 Elba Medina Kajaree Giri Dr Kavita Vishwakarma Tanuj Milagros Flores CME INDIA Mohamed Hassanein 🇪🇬 محمد حسنين

Simple 2nd concept: MPGN - Subendothelial injury with Ig, complement= leukocyte infiltration =inflammation - Remember GBM protects! - So, the glomerulus makes NEW GBM below deposits= double contour=new GBM walls off deposits =thus reduces leukocyte influx= less/no inflammation

🧠 Understanding Papillary Thyroid Carcinoma (PTC) Variants 🦋 Dive into the diverse world of PTC subtypes with this detailed breakdown of histopathological features, molecular alterations, and clinical insights. 🩺✨ #ThyroidCancer #PathologyEducation #MedicalLearning

🔔Check out this Chapter 👉 Approach to Glomerular Disease by Dr. Maria Fernanda Zavala- Miranda. and Dr. Juan M. Mejia- Vilet Access the chapter here: bit.ly/ApproachToGlom… #GlomPedia #GlomCon