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Our lab recently discussed the amazing career of Matthew S. Sigman Utah Chemistry. Here are some papers: onlinelibrary.wiley.com/doi/abs/10.100… pubs.acs.org/doi/10.1021/ar… nature.com/articles/natur… science.org/doi/10.1126/sc… pubs.acs.org/doi/10.1021/ja…

Check out our paper on the cryo-EM analysis of chromatin derived from human cells! We have established a technically accessible method for analyzing the chromatin structure prepared from human cells. onlinelibrary.wiley.com/doi/10.1111/gt…

Our new paper, in collaboration with Kurumizaka’s lab, was just published: onlinelibrary.wiley.com/doi/10.1111/gt…

60 years ago this month, the Fast Fourier Transform (FFT) was introduced by Cooley & Tukey (1965) - one of the most important algorithms in signal processing and data analysis. In 1805, Gauss - studying the orbits of asteroids Pallas and Juno - came up with a method to

A student Harvard Chemistry spotted a structure with R1 = 0.9813 (!) in pubs.acs.org/doi/10.1021/ac… CCDC Cambridge 😱😱and used what he learned in #Chem255 to refine it to R1 < 0.06—after squeezing out mystery solvents. What an achievement 🥳🥳 IUCr #crystallography #education

High-throughput magnetic separator for purifying IgG from 500 clinical samples/day. Printable design: a360.co/43naWNT

Happy to share our recent work showing bulk transport of speckle material between nuclear speckles within dynamic, multi-phase, linear connections. Nonrandom interchromatin trafficking through dynamic multiphase speckle connections biorxiv.org/content/10.110…

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates: Cell cell.com/cell/fulltext/…

Need for speed: Mass photometry as a sample analysis tool for structural studies: Structure cell.com/structure/full…

Join our group in the Centre for Medicines Discovery at Oxford Univ. Centre for Medicines Discovery University of Oxford !!!! Happy to chat about any questions about the role and science. Oxford will assist with a skilled worker visa. Please RT! my.corehr.com/pls/uoxrecruit…

Amazing work from Jun Liu lab! 🤩

The 32nd paper from the #cryoEM facility in #KEK. Collaboration with Profs. Noji and Murata. Multi-stalk FoF1-ATP synthase was engineered to enhance H+/ATP ratio. Cryo-EM structures clearly showed the presence of multi-stalks! Outstanding work, Ueno-san! nature.com/articles/s4146…

🍃➡️🧬 First paper from the Martynowycz Lab! Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by #MicroED No crystallization screens, no MR bias. Watch the diffraction-to-density movie & grab the preprint below! biorxiv.org/content/10.110…

Our work, co-led by Alfredo Flórez and @NicholasLue, is finally out in NatureStructMolBiol. Shout out to coauthors P.Grob, B. Kaeser, J.Fang, and Susanne Kassube for their contributions, and thanks to the reviewers for their suggestions that led to the final work. nature.com/articles/s4159…

🎉 Congrats to Yanhe, Kangkang, @AmirrasoulTava1, Long Gui & co-authors for revealing the atomic structure of RS3, a Giga-sized complex in motile cilia! A tour de force in #cryoET, #cryoEM,#proteomics & modeling. Out now in Nat Struct Mol Biol! doi.org/10.1038/s41594… Cell Biology UTSW

In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET. The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.

AI-guided cryo-EM analysis untangles uromodulin lattices that safeguard kidneys dlvr.it/TLpDHr

Turns out they said yes! statnews.com/2025/07/21/cas…

An evolving landscape of PRC2–RNA interactions in chromatin regulation, by Aguilar Rodrigo Aguilar, Rosenberg, et al. now in print! Learn the latest about how Polycomb works with RNA in epigenetic regulation: nature.com/articles/s4158…

First cryo-EM map of Apoferritin from our new 日本電子株式会社 / JEOL Ltd.【公式】 JEOL USA JEOL EUROPE cryoARM300-II with Direct Electron Apollo detector. Collected over night and processed in 1 day with CryoSPARC using all-default settings from only 76k particles. H/R B-factor=28 at 1.5A. Not too