BREAKING: a saliva #COVID19 test developed by @yalesph researchers has recieved emergency use authorization by the FDA. #SalivaDirect is fast, inexpensive, and non-invasive. It can be a game changer for accessible testing. news.yale.edu/2020/08/15/yal…

Today we published a work that outlines a fundamental step in how NMDA receptors, an ion channel that controls connectivity between neurons, primes itself for opening. This has implications for how other channels activate, and provides a new drug target. cell.com/neuron/fulltex…

Unliganded receptor gating matters. Check out this new article in @EurJPharmacol on how changes in intrinsic receptor activity impact agonist potency and efficacy. authors.elsevier.com/a/1jZui3G5rv059 — Full version available for a short period! #Pharmacology #ReceptorTheory

NIPER Hyderabad organised an Expert talk on "From Ligand Binding to Receptor Activation: Insights into Nicotinic Receptor Mechanism." by Dr. Dinesh Indurthi, Research Scientist, Department of physiology and Biophysics, University at Buffalo. #suny #niperhyd #ligand Department of Pharmaceuticals 🇮🇳

Glad this is out! Low- and high-affinity agonist binding are key for receptor activation. This study reveals structural correlates of this step, showing switch from L->H affinity conformations. A ~180° flip of the agonist in the process is notable doi.org/10.7554/eLife.… eLife - the journal