I am excited to see my first PhD work at deWitLab finally online!📄 It took us a few months to discover that ZNF143 is not involved in chromatin loops and a few more years to understand its actual function. If you work on 3D genome and gene regulation, check out this thread🧵:

Nice thread describing careful work from Anders Sejr Hansen and deWitLab showing showing (among other things) that an anti ZNF-143 antibody cross-reacts with CTCF, leading to inaccurate conclusions in prior studies (1 / 4)

Please RT and tell potential candidates: PhD student and postdoc position available in my lab to work on control of telomere maintenance by ALT in pediatric cancer and ways to exploit this in therapy (funded by KiKa). Email me at [email protected] to apply.

🚨New Review🚨 There's a long history of evidence for DNAme antagonism of CTCF in mammals. How important is it in normal dev. or disease contexts? Noordermeer lab 🇺🇦 Ana Monteagudo-Sánchez and I put together a summary in this collaborative review NatureStructMolBiol (1/4) rdcu.be/dBDFD

Honored to be among the recipients of the NWO Open Competition M1 grant! We will develop tools to improve our understanding of TCR-antigen interactions, using high-throughput screening & AI. Stay tuned for a postdoc vacancy to join this exciting project! nwo.nl/en/news/ninete…

Check out our COGEDE review on loops in the 3D genome. We describe how genomic regions are brought together, i.e. loop extrusion, compartmentalization and protein-protein interactions and how these processes influence each other. With Mikhail Magnitov sciencedirect.com/science/articl…

The review📚 me and deWitLab were working on during the summer break is finally out. We summarised the current state of the chromatin looping research and outlined how loop extrusion and compartmentalisation mechanisms interact. Enjoy the read!

Save the date! June 7th Collège de France in Paris, the latest developments in the making of human pseudo-embryos in vitro🤘Open access👍 no registration 🙏RT Alfonso Martinez Arias Jacob (يعقوب) Hanna Nicolas Rivron Dr Naomi Moris Alain Chédotal Treutlein lab #JFGuerin #ERialSebbag the Node

Come join us in Oxford as an Associate Professor in Molecular and Cellular Biochemistry. We are considering a wide range of research areas, but I would note that we have a vibrant chromatin and gene regulation community. Happy to answer questions if you are interested. Please RT!

Interested in using degron tagging to study the function of your favourite protein in genetically engineered mouse models? Check out our review covering recent work in this area: doi.org/10.1242/dmm.05…

Demis -- I think AlphaFold3 is really exciting. As Reviewer #3, I got great results from the server. I tried hard to get nature to urge you to release the code but was unsuccessful. I did not get it for re-review so I don't know if you responded. So why no code? Google DeepMind

Might attempt to model a flotillin cage using the AlphaFold3 web server was super fun (original paper: biorxiv.org/content/10.110…). Read the thread for a crazy plot twist!🧵👇

Immunotherapy before surgery for patients with metastatic melanoma appears to be successful as 59% of patients responds so well that adjuvant treatment is no longer needed, show the results of the NADINA trial presentend at #ASCO24 today by Christian Blank bit.ly/3Vo1hnn

I'm #hiring a PhD student! Join the Lindeboom Lab at the The Netherlands Cancer Institute on an exciting project to explore oncogenic transcription factor binding kinetics and biophysics using state-of-the-art technologies! Apply now or share this exciting opportunity! nki.nl/careers-study/…

(1/16) Check out our Simon Gaudin paper tiny.cc/icuazz from the Canzio lab out in Science Magazine today on how tuning local cohesin trajectories enables differential readout of the clustered Protocadherin (Pcdh) locus across different types of neurons.

Paper 🚨! Ecstatic, proud, grateful …Years of dedication from the whole lab, with the exceptional Daan J. Kloosterman and the one of a kind #JohannaErbani at its helm. What a journey all the way to Cell! How did it start (& end)? A 🧵1/n cell.com/cell/fulltext/…