Our opinion piece is out today, "The origin of novel traits in cancer"! Do the phenotypes come first and only later are they locked in by genetic or epigenetic changes? Insights from evolutionary biology are super useful for understanding cancer! cell.com/trends/cancer/… #S_Frank

FixNCut: A Practical Guide to Sample Preservation by Reversible Fixation for Single Cell Assays bio-protocol.org/en/bpdetail?id…

SeuratExtend: An Enhanced Toolkit for scRNA-seq Analysis github.com/huayc09/Seurat…

Earlier this week we carried out a preliminary analysis of our first 10x Genomics Xenium prime (5,000 gene) run. We had designed this experiment to get a sense of how the prime chemistry performed compared to the Xenium V1 chemistry.

Our new #paper is out in Nature Immunology. Applying #spatial transcriptomics at subcellular resolution to 130 ovarian #cancer tumors, followed by data-driven experimental design and high content #CRISPR screens to map immune evasion in ovarian cancer nature.com/articles/s4159… (1/15)

Using single-cell and spatial transcriptomics data, FlowSig provides a unified signaling modeling framework by connecting intercellular communication mediated by ligand-receptor interactions and intracellular gene expression modules. nature.com/articles/s4159…

(1/n) Excited to announce a new article with Rafael Irizarry Avi Sahu & Lab (hiring)🇺🇦 describing our approach scDist for finding cell types with transcriptional changes between conditions in single-cell data! nature.com/articles/s4146…

FixNCut: A Practical Guide to Sample Preservation by Reversible Fixation for Single Cell Assays bio-protocol.org/en/bpdetail?id…

FICTURE: scalable segmentation-free analysis of submicron-resolution spatial transcriptomics | Nature Methods nature.com/articles/s4159…

3D cellular CODA maps of the fallopian tube are used to guide the design of "assembloids" that recapitulate the complex architecture and ciliated-based motion of oocytes. See more here: science.org/doi/10.1126/sc…

STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging | bioRxiv ⁦Dr. Jasmine Plummer 👩🏻‍🔬🧬🇨🇦🇺🇸⁩ ⁦Holger Heyn⁩ ⁦@pascual_reguant⁩ ⁦@eliseinsing⁩ ⁦CNAG⁩ ⁦Adelaide Centre for Epigenetics⁩ ⁦St. Jude Research⁩ biorxiv.org/content/10.110…

🚀 Excited to share our new publication in Nature Biotechnology! We explore scalable strategies for phenotypic screening using innovative methods with to address the challenges when the number of candidates is simply too large. Check out the details tinyurl.com/5f8vjhpp! (1/10)

Happy publication day for us! Labor of love with Lan Coffman lab #TLS #ovariancancer UPMC Hillman Cancer Center University of Pittsburgh The activity of tertiary lymphoid structures in high grade serous ovar... sciencedirect.com/science/articl…

snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives👏 nature.com/articles/s4200…

Interactive design and validation of antibody panels using single-cell RNA-seq atlases biorxiv.org/content/10.110…

1/🧵Excited to re-introduce Memento in (cell.com/cell/fulltext/…), a scalable method for differential analysis of scRNA-seq data. It provides first-in-class performance in statistical power and calibration for comparing differences in mean, variability, and gene correlation.👇

This is great! NIAID News have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov

A protein expression atlas on tissue samples and cell lines from cancer patients provides insights into tumor heterogeneity and dependencies. nature.com/articles/s4301…

📢Excited to share our work on bioRxiv "Spatiotemporal map of the developing human reproductive tract at single-cell resolution"! Beyond grateful to our amazing team Cecilia Icoresi Mazzeo Luz Garcia Alonso roser MarioniLab and collaborators for their contributions. 🧵[1/10]

Excited to share our recent manuscript out at nature . DanPiraner and Majo Duran from Roybal Lab and Mohamad Abedi and Adam Chazin-Gray in David Baker's lab engineered synthetic receptors that sense natural and designer soluble cues. nature.com/articles/s4158…