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What do you do when you have a ton of amazing creators in one place? Put on a charity stream LIVE from St. Jude! Join us Wednesday April 24 as we celebrate community and everything St. Jude PLAY LIVE has done for the last 10 years! Hosted by Sam Lupo & Broman

I may not get to see many of the people coming for St. Jude PLAY LIVE this year but y’all are amazing and you can’t even begin to imagine how appreciated you are by the St. Jude community. Have a blast and keep being awesome!

Channeling my inner DrLupo for the Star Wars event…

Bikes, bites, and Battlestar Galactica for Mother’s Day…

.Xiao Li, Gamuyao, CC_Lab et al. @stjuderesearch engineer a #LipidDroplet (LD)-targeting motif and develop a tool kit that can track contact sites between LDs and other organelles in living cells. hubs.la/Q02F1yfK0 Daniel Stabley Alex Carisey Alison Tebo

Challenger tour action…

🌟 Pre-vacation #MicroscopyMonday magic rendered by Daniel Stabley! 🌟 This is a showstopper: our top plasma membrane probes light up neurons and glia. But wait, there's more! The grand finale? A lattice light sheet stunner showing off its isotropic prowess in the XZ view.

Yeah, it’s going to be that kind of weekend…

It's #FluorescenceFriday, so here's a Lattice Light Sheet volume of some 3T3 cells (labeled: microtubules and DNA) from one of our in-house built microscopes. Rendered with Allen Institute Agave.

Path-traced render of the nucleus of a 16x expanded 3T3 cell stained for total DNA as imaged via Lattice Light Sheet #Microscopy for #FluorescenceFriday.

Memphis sunset…

Please RT! We are very proud to announce LSFM 2025!  The light-sheet conference/workshop will be held this year June 1st-7th, 2025, at the Mount Desert Island Biological Laboratory (MDIBL) MDI Biological Lab in Bar Harbor, Maine. Application portal open now! Application deadline

The Big Green Egg + Blackstone reverse sear is the ideal steak technique, change my mind…

Beyond excited to share my big St. Jude news! We’re going to build an amazing hub for imaging technology development and deployment - driven by St Jude’s mission to transform the way the world understands and treats pediatric catastrophic diseases. Imaging innovators come join us!

Why is it always "vibe coded this game with Claude in an hour" and not "vibe coded this re-write of SIM reconstruction in an hour so an entire field isn't dependent on CUDA code from 10 years ago".

Today has been AMAZING! Shoutout to all of you incredible humans who experienced the St. Jude campus today! We are so grateful for you being here!

Through the years…

Current vibes…

The MOSAIC reconfigurable microscope by Eric Betzig et al is finally out! MOSAIC integrates multiple advanced imaging techniques including light-sheet, label-free, super-resolution, and multi-photon, all equipped with adaptive optics: biorxiv.org/content/10.110…

Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… Eric Betzig Legant lab