Nassim Nicholas Taleb spent 21 years as a risk taker before becoming a researcher in philosophical, mathematical, and (mostly) practical problems with probability. He is the author of the Incerto, a five-volume philosophical essay on uncertainty. 12 timeless wisdom from

Fermi to Dirac claiming priority (Dirac acknowledged the omission).

"classically undruggable" keeps the ambition of drugging tough targets while avoiding the nit-picking that often surrounds the term "undruggable".

~400 fragments+chemoproteomics in live cells identifies new ligands against > 2000 proteins, and machine learning provides rules for ligand binding and localization practicalfragments.blogspot.com/2024/05/fragme… Science Magazine Georg Winter Enamine Ltd 🇺🇦

I keep being amazed by the work from Revolution Medicine Here is a example from their last patent. This work is again pushing medicinal chemistry out of out comfort zone. 6 chiral centers, 1 atropisomer , a spiro and an aziridine ! Congratulations to Les Burnett and all the Team!

A great MedChem meeting with wonderful people. rict2024.org

Complexity artists claim to make the unpredictable predictable. I prefer to work on making the unpredictable irrelevant.

This should be a great student resource. Atkins is one of the true greats among textbook writers. chemistryworld.com/news/physical-…

Our long term collaboration with Boehringer Ingelheim yields fruits: 3+2 Extravaganza just published in J Org Chem/Org Lett ! University of Vienna STEM CeMM pubs.acs.org/doi/10.1021/ac… #academiaindustry #medchem

We are looking for a post-doc with a background in immunology to work on the impact of RAS oncogenic signaling on the interaction of lung cancers with the immune system. Fully funded four year position at Francis Crick Institute in London. #Crick crick.wd3.myworkdayjobs.com/External/job/L…

This is possibly the funniest SNL skit ever made, lol

We mourn the loss of Ivy Elkins , a pillar of the #LCSM community. We commiserate with EGFR Resisters and the entire lung cancer community during this difficult time. May her legacy continue to inspire us in the fight against lung cancer. #InMemoryOfIvy #LungCancerAwareness

Stunning interim clinical trial data from Revolution Medicines... PFS = 8.1 mo in 2nd line KRAS G12-mutant metastatic #PDAC. OS not yet reached, but already more than a year! Benchmark PFS for this group is 2-3.5 months, behnchmark OS is 6.1-6.9. 1/

Peter Ertl has recently retired from Novartis. Here's a link to his website #cheminformatics #chemoinformatics #CompChem #MedChem #DrugDiscovery #DrugDesign #chemtwitter peter-ertl.com

Last year, ~7% of the Protein Data Bank (PDB) structures came from this facility in England. Their X-ray crystallography throughput is near the top of the global leaderboard, and it's only accelerating. I was fortunate to take a tour of Diamond and now you can too.

Delighted to see this work published in Nature Cancer

Stay tuned for #WCLC24

Excited to co-organize the virtual EACR Boehringer Ingelheim Conference: Drugging & Regulating the MAP Kinase Pathway! Submit an abstract or join us. Please RT and share with others. Details & registration: eacr.org/conference/boe…

🎉 Happy Birthday to Friedrich August Kekulé! Born on September 7, 1829, in Darmstadt, Germany. 🧪💭 He is best known for assigning a cyclic structure to benzene’s C6H6 formula, which is famously said to have come to him in a day dream chemistryviews.org/details/ezine/…

This morning at #WCLC24, Piro lito, MD, PhD, will present during a "Meet the Expert" session on pan vs. allele specific KRAS inhibitors.#lcsm 7:30 a.m. PT (10:30 a.m. ET) | 30DE Memorial Sloan Kettering Cancer Center