A new #ScienceReview looks at a different approach to drug discovery that may enable drugging of unconventional targets through stabilization of macromolecular complexes with molecules known as “LOCKTACs.” Learn more: scim.ag/4lAiKmF

Did you know amphibians and fish have viruses that are very similar to human influenza B viruses? We didn't know either, but Eddie Holmes found them and we had a closer look at their HAs and NAs. with Gagandeep Singh| ਗਗਨਦੀਪ ਸਿੰਘ The Ward Lab Robert P. de Vries Disha Bhavsar science.org/doi/10.1126/sc…

Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child pnas.org/doi/abs/10.107…

Exciting to see our protein binder design pipeline BindCraft published in its final form in nature ! This has been an amazing collaborative effort with Lennart, Christian Schellhaas, Sergey Ovchinnikov, Bruno Correia and many other amazing lab members and collaborators. nature.com/articles/s4158…

Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX. Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures. rbvi.ucsf.edu/chimerax/data/…

🔍 Look the statistics in #France regarding to #mosquito borne #arboviruses notified by the end of Aug‼️ 🦠 228 #Chikungunya cases 🦠 15 #Dengue cases 🦠 15 #WestNile human infections 🦟 #VectorControl interventions are key to reduce risks of transmission ✔️

Nature research paper: One-shot design of functional protein binders with BindCraft go.nature.com/4g0R09u

De novo design of light-responsive protein–protein interactions enables reversible formation of protein assemblies ift.tt/rc5lnRI

One of the most important questions in the longevity field is whether an aged environment will wear out young cells, or if young cells will de-age an old environment. Incredibly important paper below pointing to the former!

Dengue virus infection reprograms baseline innate immune gene expression: Med cell.com/med/fulltext/S…

RFdiffusion2 is now on Github under the RosettaCommons umbrella. Developers from the IPD are working with the Rosetta Commons Devel Team to get the inference code up and running in its new home. github.com/RosettaCommons… Nice!

Our new study is out at Cell Reports! We used 53 sarbecovirus pseudoviruses and 17 ACE2 expressing cells and demonstrated that 4 residues in spike contribute to the expansion of ACE2 usage range. Congrats Yusuke🎊! cell.com/cell-reports/f…

1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk | Science science.org/doi/10.1126/sc…

"A single plasmid encodes TrmA fused to a protein of interest, covalently linking the variant proteins to RNA barcodes in vivo. The barcoded fusion proteins are utilized for epitope binding, protease cleavage, and solubility, with activity measured by DNA sequencing read counts."

Today in Science Magazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The

Predicting protein-protein interactions in the human proteome | Science science.org/doi/10.1126/sc…

Here's the paper itself. If you're interested in joining the team to turn this into a medicine, please reach out science.org/doi/10.1126/sc…

Out Now! Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor bit.ly/3KnDn8H #EpsteinBarrVirus #Desmocollin #Microbiology

🚀🚀David Baker paper from Science Magazine is here!! Can a computationally designed IL-21 mimic overcome the limitations of native IL-21 for cancer immunotherapy while maintaining safety and efficacy?Institute for Protein Design NIH "Design of a potent interleukin-21 mimic forcancer

Disulfide-constrained Fabs overcome target size limitation for high-resolution single particle cryoEM | Nature Communications nature.com/articles/s4146…