Come be a split EM/ECI postdoc like me! This is a very cool project for those interested in unknown identification.

We are looking for a PhD candidate who is enthusiastic about discovering the function of enzymes and metabolites in Mycobacterium tuberculosis using genetic screens and untargeted metabolomics. Interested? Please apply before May 26th! ru.nl/en/working-at/… #jebentnodig

Many congrats to Lorenzo and the entire team! Credentialing is a powerful yet unexploited branch of metabolomics and herein, we devised a nice approach to help tackle these projects in yeast.

Thank you very much Emma Schymanski Corey Griffith Lorenzo and Carole for submitting your work to ABC! GNPS - UC San Diego Luxembourg Centre for Systems Biomedicine uni.lu Luxembourg National Research Fund (FNR) #metabolomics

Pass this immediately!

A real SinFonia led by our coordinator Pablo Iván Nikel @pabnik.bsky.social ! In front of the Opera House in the eternal city, in the occasion of our final meeting, but is it so? I doubt it 😎 we will continue playing 🙌🏻

High-throughput Saccharomyces cerevisiae cultivation method for credentialing-based untargeted #metabolomics by Lorenzo Favilli et al Luxembourg Centre for Systems Biomedicine uni.lu Emma Schymanski Corey Griffith #yeast #chromatography #labelling #spectrometry #OpenAccess link.springer.com/article/10.100…

Come join us! We are looking for a Postdoctoral Researcher in Mass Spectrometry Workflows for Unknown Chemicals to join the Environmental Cheminformatics group at Luxembourg Centre for Systems Biomedicine uni.lu #TeamMassSpec #cheminformatics #OpenScience Interested? Apply here⬇️ emea3.mrted.ly/3h2lg

Interested in rare diseases, mitochondria, non-target mass spectrometry #TeamMassSpec #cheminformatics and identification? Exciting #postdocposition in GENOMIT consortium with rare disease cohort at Luxembourg Centre for Systems Biomedicine uni.lu in the Linster & Schymanski groups! emea3.mrted.ly/3fyae

What a great team! #environmental #cheminformatics Luxembourg Centre for Systems Biomedicine Emma Palm @DagnyAurich Federica Vero Hibahmt Anjana Natarajan Bego Talavera Camilla Parviel Chirsir Lorenzo Corey Griffith (out of pic Gianfranco Frigerio )

Congrats on the promotion Emma Schymanski!! 🎉🥳

So very proud of my friend and colleague, Lorenzo! Congratulations! 🥳

biorxiv.org/content/10.110… Nice follow up by Dr Mohammad Tauqeer Alam on his earlier work on enzyme inhibition doi.org/10.1038/ncomms…, now showing how frequent metabolic enzyme activators let metabolic pathways talk to each other

Zebrafish model for CLN3 Batten disease recapitulates the human metabolic signatures of BMP depletion and accumulation of glycerophosphodiesters and cholesteryl esters at larval stages life-science-alliance.org/content/7/3/e2…

The TCA cycle is fraught with metabolite damage. Here we describe a universal repair enzyme that prevents the TCA cycle from poisoning itself: link.springer.com/10.1038/s41467…

(Nature MS) A spectroscopic test suggests that fragment ion structure annotations in MS/MS libraries are frequently incorrect dlvr.it/T2lZ8j (RSS) #nature #MassSpecRSS

Looking forward to this afternoon's session on "Enzymatic control of problematic intermediates" at #DiscoverBMB! Three metabolite repair talks in a session - this may be a record!

Happy to share this preprint of my postdoc work on discovering that CLYBL repairs malyl-CoA to avert methylmalonyl-CoA mutase inhibition and loss of vitamin B12! Thanks to the team for all your help! #MetaboliteRepair biorxiv.org/content/10.110…

#MetaboliteRepair enzymes have evolved to eliminate often toxic non-canonical metabolites. Out today in Nature Chemical Biology, we found that CLYBL repairs malyl-CoA, a TCA cycle side-product, to avert vitamin B12 depletion doi.org/10.1038/s41589…