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Wow! What an eye opening session on Sex as a biological variable in research. My personal favourite was Rayyan Gorashi, MS for studying the role of sex linked genes in regulating responses to stiffness. Special thanks to Brian @BrianAguado for his insightful conversations. - SS 12th World Biomaterials Congress (WBC 2024)

Bringing to you cool work by my labmate Nicole from Confinement Mechanobiology Lab at MBI on understanding the role of mechanical memory in confined cells migration. Signing off for the day -SS 12th World Biomaterials Congress (WBC 2024) #Biomaterial #mechanobiology

Welcome to the final day of 12th World Biomaterials Congress (WBC 2024). The "Young"-sters Ranmadusha Hengst Martin Kiwanuka from the soft nano-biomaterials lab Jennifer Young at Mechanobiology Institute are taking over the Confinement Mechanobiology Lab at MBI channel. Stay tuned! -RH & MK #biomaterials #WBC2024

True Regeneration is when we control inflammatory responses. Great talk by Prof.Milica Milica Radisic on using citric acid based polymers as 3D tissue velcros for reduction in invasiveness of surgeries. - RM & MK 12th World Biomaterials Congress (WBC 2024) #biomaterial

Great keynote from Ali Khademhosseini at Terasaki Institute for Biomedical Innovation discussing the different applications of GelMA in tissue engineering and regenerative medicine at 12th World Biomaterials Congress (WBC 2024). -MK & RH #biomaterials #WBC2024

Learning about the importance of scaffold design and long-term testing of heart valvular implants. Really inspired by the keynote speaker Dr. Carlijn Bouten TU Eindhoven. 12th World Biomaterials Congress (WBC 2024) - RH & MK #WBC2024 #biomaterials

Amazing work by Prof Kristopher Kilian Kristopher Kilian UNSW on cancer shapeoids using hydrogel microstructures of varying stiffness and geometry 12th World Biomaterials Congress (WBC 2024) - MK & RH #biomaterials #WBC2024

Awesome talk by Samuel Maher from the Cell Mechanobiology Choi Lab Yu Suk CHOI on using the gradient hydrogel system to understand the role of volume adaptation in regulating stem cell function. - RM & MK 12th World Biomaterials Congress (WBC 2024) #Biomaterial #mechanobiology

Congratulations to Yeji from Confinement Mechanobiology Lab at MBI for the best poster award at the 12th World Biomaterials Congress (WBC 2024). She is exploring the activation of fibroblasts as a function of confined migration. You go girl !! - RH & MK #Biomaterials #WBC2024

All good things must come to an end! Signing off on the last day of WBC2024. Cheers to all the amazing scientific talks and beautiful connections. Thank you everyone for making this a great experience. Special thanks to Yu Suk CHOI, Jennifer Young, Hwang lab, Jennifer Shin - RH,MK,SS

Excellent study by the Marta Shahbazi lab! Physical separation of epiblast cells from the basement membrane enables germ cell specification by releasing an integrin-mediated block. Great example of physical cues guiding #pluripotent cell fate! -MC science.org/doi/10.1126/sc…

Check out our latest review! We dive into the physical environment of primordial germ cells and explore the role of #confinement and mechanics in guiding their journey to a #germline fate. Stay tuned for more on germ cell #mechanobiology! journals.physiology.org/doi/abs/10.115…

An exciting study from the Konstantopoulos Lab lab reveals that extracellular fluid viscosity alone can drive adipogenic-to-osteogenic stem cell transition, even under adipogenic-favoured conditions. A promising step for the future of #StemCellTherapy ! -YJ science.org/doi/full/10.11…

It's always fascinating to observe cell migration in #confinement in vivo! This study from Stefano Zapperi and Caterina La Porta et al used intravital multiphoton microscopy to uncover a multicellular, low-cohesion mode of HT1080 collective migration-GX doi.org/10.1073/pnas.2…

Tumbling=better #StemCell differentiation? A Nature Materials study by Manish Ayushman et al showed ‘cell tumbling’ under #confinement in sliding hydrogels enhances cartilage formation by impacting nuclear #mechanotransduction & chromatin accessibility-SS nature.com/articles/s4156…

Fascinating in vivo tracking of collective cell migration under confinement PNASNews! Reveals self-organized antiparallel streams and compressive ECM deformation. Now wondering: How do single cells navigate these complex microenvironments? 🤔 -LY www-pnas-org.libproxy1.nus.edu.sg/doi/10.1073/pn…

Surprise! 🤯Acute #chromatin decompaction stiffens nuclei (not softens!) via swelling & #lamin changes. Nanopillars reveal this time-dependent effect. Metastatic cells dodge stiffening by compacting chromatin—key for #confinedmigration. -NL biorxiv.org/content/10.110…

How do cells 'feel' confinement? New research reveals how mechanical confinement compresses the #nucleus, triggering immobile cells to spread and migrate. -YJ sciencedirect.com/science/articl…

Very cool finding🧩: It doesn’t matter if a cancer cell is more or less deformable, it still makes similar choices when navigating #confinement. Gijsje Koenderink team shows that “squeezability” alone doesn’t explain how cells pick their path!

Just a few days to submit for the Sep 9-12 Mechanobiology Institute conference! Cool feature this year- a #HawkerCentre night with speakers and ECRs. Imagine enjoying Char Kway Teow & chatting #microtubules with someone like Sasha Bershadsky! Register here: mbi.nus.edu.sg/events/mbiconf…