The Galej Group provides new insights into the minor spliceosome, a vital RNA-protein complex involved in gene expression. These results allow a better understanding of its mechanism, whose dysfunction is associated with several genetic disorders. embl.org/news/science-t…

Congratulations, Flora Vincent! 👏 The EMBL Group Leader received the Planet Earth Award 2025 from the Alliance of World Scientists for her research on microbial interactions in the ocean and their role in climate regulation. embl.org/news/awards-ho…

Interested in RASopathy and RAS-driven cancers? This month we feature SHOC-MRAS holophosphatase complexes.....CPX-25716, CPX-25719, CPX-25720. Visit the Complex Portal to learn more!

Complex Portal release 250 is out! 5,049 manually curated biological complexes. ebi.ac.uk/complexportal/… (in sync with UniProt release 2025_02)

Complex Portal release 250 is out! 5,049 manually curated biological complexes. ebi.ac.uk/complexporta... (in sync with UniProt release 2025_02). Come explore our high quality manually-curated complexes.

Hey Spliceosome enthusiasts! Explore the Spliceosome's catalytic activity on pre-mRNA through a highly dynamic series of compositional states. Visit the CP & use the Navigator to compare human Spliceosome complexes from various points in their lifecycle (tinyurl.com/yy4fbcp2).

IntAct is expanding its Inflammatory Bowel Disease dataset (lnkd.in/ejkr8tKx)! Our latest addition is the lncRNA GATA6-AS1 interactome, from K.E. Sosnovski et al. (2023) in Caco-2 cells (lnkd.in/eiYaFSdK). ➡️ Learn more about this! (lnkd.in/e2RSQEZZ)

We're excited to promote our range of Dynactin & Dynein complexes this month! Visit the Complex Portal to explore the respective orthologous and paralogous complexes! (ebi.ac.uk/complexportal/…) #Dynactin, #Dynein, #Intracellulartransport

Thrilled to announce that the protein–protein interactions of 396 SLC transporters, from the RESOLUTE project, is now integrated into IntAct! Congratulations to #Superti-FurgaLab, #FabianFrommelt Explore the interactome at ebi.ac.uk/intact/search?…

May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). See the complex in tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-associated proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #SunSafety🧴

It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct_EBI, #ComplexPortal, #UniProt, #MelanomaAwareness, #SunSafety, 😎📷🧴

Now published in Mol Syst Biol embopress.org/doi/full/10.10…

June features CUL4A (Q13619). Cullin4-RING E3 ubiquitin ligases (CRL4s) regulate processes including facilitating stalled fork stability & genome integrity. Search using GO:0080008 (tinyurl.com/2zhsy43s) & use the Navigator to explore our range of CRL4 complexes! #ubiquitin

UniProt is a world-leading, freely accessible data resource that provides protein sequence and functional information to scientists worldwide. So what is the value of UniProt for the global scientific community? #FAIRdata #Bioinformatics

Want to learn more about macromolecular complexes? Register for our webinar on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 & MuSIC). ➡️ Register:tinyurl.com/bdy6wttv

Intronic repeats play a role in evolution, gene regulation & disease. They're linked to disorders like Haemophilia. Cells keep them in check through RNAi-driven heterochromatin formation. See S. pombe CLR4 complex (CPX-9241) & learn about its role in transcriptional silencing.

🐍 From Dark Myths to Eco Allies: Celebrating #WorldSnakeDay Complex Portal holds curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake with pharmacologically active venom proteins. 🔬 Explore these complexes: (See tinyurl.com/mz5hmzdf)

Do you work with reference proteomes? We are improving our pipeline: Increasing the number of proteomes Decreasing the number of proteins in UniProtKB Better representing the biodiversity of life Read more: insideuniprot.blogspot.com/2025/06/captur…

All our training & webinars are free and available on demand? Our live webinars are taking a summer break but you can access our recorded webinars & training material online. View all UniProt training: ebi.ac.uk/training/servi… UniProt YouTube channel: youtube.com/c/uniprotvideo…