Excited to share, our #nanopore work is just published in Nano Letters !! We propose a new strategy to develop an artificially intelligent (#AI) nanopore with machine learning (#ML) and the quantum transport approach. #nanotechnology #DNAsquencing doi.org/10.1021/acs.na…

We received the hard copy of the Trends in Biosensing Research book - Annina’s 1st book chapter (+ co-authors Til & Julian, aka Team Nanopore)! We covered solid-state nanopores for biomolecular analysis & detection. Thank you for this opportunity Nicolas Plumere & Fred Lisdat! 🧬

Rearranging mammalian genomes with recombinases to study structural variants at scale provides insights into genome organization and dispensability. science.org/doi/10.1126/sc… and science.org/doi/10.1126/sc… #NBThighlight

Step-by-step guide to detecting A-to-I editing! Nanopore sequencing to detect A-to-I editing sites. #nanopore #DRS #Edit doi.org/10.1016/bs.mie…

Most human cells in your body do not have DNA / genomes. ~ 90 % do not have DNA. ~ 10 % have DNA

“The leaders of the Human Genome Project always knew they were just starting a conversation” The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do go.nature.com/3Ck1qBP

[Review]Toward single-molecule protein sequencing using nanopores. Author predict that, more likely than not, nanopores will be capable of identifying full-length proteins at the single-molecule level and with single-amino acid resolution, paving the way to single-molecule

🚨 Big news! As promised, we’ve open-sourced the CpGPT codebase — bringing this powerful DNA methylation foundation model to researchers and developers worldwide: github.com/lcamillo/CpGPT/ 🖥️ The release includes model architecture, fine-tuning scripts, pre-trained weights, and a

New Huang lab publication. A comprehensive review of nanopore environmental analysis. And, it is open access, which should be convinient for most readers. pubs.acs.org/doi/10.1021/ja…

A milestone for our lab! Here's a full text link: rdcu.be/egmYb

Nature research paper: Human de novo mutation rates from a four-generation pedigree reference go.nature.com/3ECWGs2

On the days I feel lost, I return to this, and it always reignites me.

Targeting DNA damage in ageing: towards supercharging DNA repair nature.com/articles/s4157… This new Review discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases

New online! Structural variants in the 3D genome as drivers of disease bit.ly/44FiIo5

Misha Kolmogorov National Cancer Institute Children's Mercy Oxford Nanopore UMD Department of Computer Science UC Santa Cruz Genomics Institute NY Genome Center Google Genomics Ayse Keskus NIH researchers create algorithm to detect somatic structural variation in cancer genomes using long-read sequencing #NBTintheNews via OncoDaily oncodaily.com/insight/somati…

A telomere-to-telomere map of somatic mutation burden and functional impact in cancer biorxiv.org/content/10.110… #biorxiv_genomic

Also check out the other preprints as part of the SMaHT Network including the flagship paper. Many thanks to the entire consortium for working together to make this happen. yay team science! biorxiv.org/content/10.110…

From JAMA: #Microplastics are increasingly detected in human tissues, with potential links to cognitive, cardiovascular, and inflammatory outcomes. 📌 Learn more in this JAMA Insights: ja.ma/4nROUvH

Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic go.nature.com/4qa6m0d

"Toward Same-Day Genome Sequencing in the Critical Care Setting" nejm.org/doi/abs/10.105…