In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

✅ The @ERN_RECONNET - #SLICC - @SLEUROSOCIETY consensus on RARE #LUPUS MANIFESTATIONS has just been published in The Lancet Rheumatology (FREE LINK: authors.elsevier.com/a/1l8og9UBHvvg…) and it's the opportunity to ask YOU this very interesting question: how would YOU define rare in #medicine?

New content online: 2023 International Rome consensus for the nomenclature of Sjögren disease bit.ly/4mQYPSh

🔴 NEW EULAR recommendations for #SLE with #kidney involvment (2025)! ➡️ early biopsy ➡️ early combination ➡️ non immune treatment #EULAR2025

"H Syndrome" review of 23 French pts. Autoinflammatory dz due to variants of SLC29A3 gene. Multisystem histiocytic lymphoproliferative disorder of young adults- skin 2/3, sensorineural hearing loss, fever w/ endo & autoimmune dz. Best responses w IL6 inhib. #EULAR2025 Abst

Procalcitonin can be used in the monitoring of infection, but is also high in Stills disease. 89 AOSD pts showed pts w high PCT had more pleuritis, MAS,^LFTs, & correlated w/ Dz activity, CRP, LDH, hi ferritin & normalized w bDMARD Rx. #EULAR2025 abstr #POS1118

🚨 NEW classification criteria for #ASyS #antisynthetasesyndrome presented by Rohit Aggarwal and Lorenzo Cavagna ➡️ clinical domain ➡️ other clinical features ➡️ serologic domain Great achievement! 👏🏼👏🏼👏🏼 #EULAR2025 EULAR ACR_Journals Annals of the Rheumatic Diseases

Prognosis of essential mixed cryoglobulinemia and connective tissue disease-related cryoglobulinemia after rituximab-induced remission academic.oup.com/rheumatology/a…

Please to share our comprehensive review of Clinical Features in VEXAS syndrome: a systematic review academic.oup.com/rheumatology/a…

✅ Check my visual summary for the American College of Rheumatology #recommendations for the screening 🔎 and treatment 💊 of #LUPUS #NEPHRITIS ⬇️ What would you change? Please DO let me know if an update 🔄 is needed 👍

Analysis of whole-exome seq data from MyCode & BioMe biobanks investigated assoc between UBA1 VAF and VEXAS disease manif. Results showed ↑VAF resulted in more severe disease & higher penetrance, while ↓VAF had incomplete penetrance & milder disease A&R doi.org/10.1002/art.43…

✅ What is lacking the most at the #lupus consultation, from the #patient perspective? OPEN-ACCESS FREE LINK: sciencedirect.com/science/articl…

Improved outcome of #HSCT in #STAT1 gain-of-function disease following JAK inhibition bridging. A new report from Emilie Pauline Buddingh, Catharina Schuetz et al. hubs.la/Q03zBmtQ0 #Autoimmunity #InbornErrorsofImmunity #Immunodeficiencies #Therapeutics

International Vexas statements which I have the honor to initiate and coordinate and which is finally published ! acrjournals.onlinelibrary.wiley.com/doi/10.1002/ar…

Arsene Mekinian (Arsene Mekinian)։ International Vexas’ Announcements Is Finally Published American College of Rheumatology hemostasistoday.com/science/intern… #Health #Hematology #HemostasisToday #Internal #Medicine #InternationalVexasStatement #Vexas #MedEd #MedX

Takayasu Artérite du sujet jeune très rare en France Pour mieux traiter utilisation de biothérapie à travers registre européen BIoTAKA premières données mondiales de comparaison TNF vs tocilizumab

Ian Lamborn, Helen Su et al. NIAID News review MAGIS clinical features, current genetic and biochemical understanding, and future therapeutic considerations. hubs.ly/Q03CMdcG0 #ClinicalPhenotypes #InbornErrorsOfImmunity #Diagnostics

Recent publication of the #SplenoMegaly study (SMS), with very interesting insights into the various etiologies and their possible predictive factors. A short thread with the results 🧵 🔗ojrd.biomedcentral.com/articles/10.11…

Dusan Bogunovic BogunovicLab reviews how incomplete penetrance in genetic disorders can be influenced by genetic variant quality, genetic and epigenetic modification, environment, and mosaicism. hubs.la/Q03D9j_g0 #InbornErrorsOfImmunity