Our new manuscript is online! Cas9 nickase-mediated contraction of CAG/CTG repeats at multiple disease loci biorxiv.org/content/10.110… Giant team effort! Led by the incredible Alvaro Murillo with more help from Mariah Lelos, DAVIDSON LAB, and many many more. Here's a thread.

A while ago I decided to significantly reduce the number of conferences I attend. Today is one of those rare exceptions. #GERS2024 here we go. I'm presenting after lunch, btw.

Congrats to everyone! ❤️

#RepeatExpansionDisorders are up to three times more common than current estimates. Underdiagnosis or reduced penetrance? by our wonderful dream team kibanez Matteo Zanovello Chris Clarkson + Bharati Jadhav & Andy Sharp nature.com/articles/s4159…

Excited to report that we have discovered a new, endogenous molecular clock in unmodified human cells and tissues. It is ticking away right now in almost every cell in your body. Specifically, in a new paper on BioRxiv, we show that RNA editing by the near-ubiquitous ADAR1 in

Chr16q22 has the highest density of #shorttandemrepeats in the entire genome! Fascinatingly, it harbours 3 repeat expansion disease loci associated with ataxia (SCA4,SCA31, SCA51). In Movement Disorders Journal, we characterise two repeat loci: shorturl.at/EPolJ & shorturl.at/W4rWN

Come and join the lab! we have a position available to work on the analysis of short and long-read DNA and RNA sequencing from patients with repeat expansion diseases jobs.ac.uk/job/DLG312/bio… #RepeatExpansionDisorders #RepeatExpansions #C9orf72

🧠 Happening TODAY! Join Toby Curless, Alzheimer’s Research UK PhD Student & UCL Dementia MSc alumnus, for a live Reddit AMA on r/iAmA. ⏰ 3–5pm BST ▶️reddit.com/r/IAmA/comment… #DementiaActionWeek UCL Queen Square Institute of Neurology

We are happy to be seeking three post-docs across Edinburgh Napier, Glasgow & UCL in an exciting project to investigate mechanisms linking glial ageing/longevity & neurodegeneration (MRC-funded). Positions advertised, info attached (til end of June) Fiona Kerr Nathan Woodling