Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma biorxiv.org/content/10.110… #biorxiv_cellbio

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab Stephen Elledge, Jingjing Gao from the Shao lab Susan Shao and all the co-authors! biorxiv.org/content/10.110…

While working on midnolin, the Susan Shao serendipitously solved a beautiful high-resolution structure of TXNL1 bound to the proteasome. We also show that oxidative stress caused by certain metal/metalloids leads to TXNL1 ubiquitin-independent degradation. biorxiv.org/content/10.110…

Congrats to the very talented Long-Wen Zhao from Scott Kennedy’s lab who discovered a novel system that excises transposable elements from mRNAs independently of the spliceosome. We show that this mechanism is highly conserved and occurs in human cells! biorxiv.org/content/10.110…

Thrilled to share our latest collaborative work with the teams of David Julius and Stuart Brierley nature nature.com/articles/s4158… #GRABSensors #Serotonin #Enterochromaffin

Our midnolin sequel is now published!

New online! A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients bit.ly/3GjrXRN

Great study from Chris Nardone from Rapoport Lab on organelle pH regulation! He characterized a super cool complex that assembles v-ATPase. Congratulations 🎊🍾🥳

Honored to be a Life Sciences Research Foundation fellow supported by @HHMINEWS. I’m deeply grateful to the foundation for believing in me. Exciting times ahead! lsrf.org/current-fellow…

Great to see our work finally published!

Excited to share our latest work onll LZTR1 just published Science Magazine!! A wonderful multidisciplinary collaboration between Simanshu Dhirendra's lab and our lab that provides structural understanding on RAS substrate and nucleotide specificity, and effect of mutations in LZTR1.

Wow super cool, congrats! Excited to read it over the weekend!

Congratulations to Milen Negasi, a researcher in the Xin Gu lab at Dana-Farber, who has been named to the Damon Runyon Cancer Research Foundation Scholars Program for Advancing Research and Knowledge (SPARK). The one-year cancer research internship is awarded to post-baccalaureate scholars.

Incredibly proud to host Milen in my lab as a Damon Runyon SPARK fellow! Thank you Damon Runyon Cancer Research Foundation for your generous support. It means so much for the young generation of scientists.

Read our latest #research "A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients", published with Springer Nature in NatureStructMolBiol nature.com/articles/s4159…

An RNA splicing system that excises DNA transposons from animal mRNAs | Nature nature.com/articles/s4158…